Knowing Diffuse Large B-Cell Lymphoma, a Deadly Rare Cancer

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Knowing Diffuse Large B-Cell Lymphoma, a Deadly Rare Cancer
Knowing Diffuse Large B-Cell Lymphoma, a Deadly Rare Cancer

Although rare, DLBCL or diffuse large B-cell lymphoma is an aggressive cancer and can cause death if not treated immediately. Well, by recognizing the causes and symptoms, treatment steps can be taken early on

There are two types of lymphoma or lymphoma, namely Hodgkin's lymphoma and non-Hodgkin's lymphoma. DLBCL or diffuse large B-cell lymphoma is a type of non-Hodgkin's lymphoma.

Get to know Diffuse Large B-Cell Lymphoma, a Rare and Deadly Cancer - Alodokter

This type of cancer attacks the B lymphocyte cells in the lymphatic system or the system that functions to fight infection in the body. Lymphoma can attack several organs of the body, such as the bone marrow, thymus gland, and spleen. In DLBCL, the cancer usually starts in the lymph nodes.

Common symptoms of diffuse large B-cell lymphoma are enlarged lymph nodes, excessive night sweats, sudden weight loss, loss of appetite, extreme tiredness, fever, and intense itching. normal.

In addition, DLCBL sufferers may also experience certain symptoms, such as abdominal pain, diarrhea, bloody stools, coughing, and shortness of breath.

What Causes Diffuse Large B-Cell Lymphoma ?

The main cause of diffuse large B-cell lymphoma is not known with certainty. However, this type of cancer is thought to originate from abnormal B lymphocyte cells that are larger than normal B lymphocyte cells.These abnormal cells divide rapidly and uncontrollably, then spread and damage the structure of the lymph nodes.

There are several groups that are more at risk of suffering from this DLBCL, including:

  • Age 40–65 years
  • Suffer from an autoimmune disease or have a weak immune system
  • Have undergone radiation and chemotherapy procedures
  • Have been exposed to high levels of radiation or certain chemicals

How to treat Diffuse Large B-Cell Lymphoma ?

If you feel the symptoms of DLBCL as mentioned above, immediately consult a doctor. Later, the doctor will perform several examinations to confirm the diagnosis and determine the stage or severity of the lymphoma.

Several types of examinations performed to determine the stage of lymphoma include:

  • CT scan
  • Combination of PET scan and CT scan
  • Blood test
  • Bone marrow biopsy

The results of this test will determine how far the tumor has spread and what treatment steps will be taken. Well, there are several treatment methods used to treat diffuse large B-cell lymphoma, including:


Chemotherapy is the most commonly used treatment to treat DLBCL. This method is better known as R-CHOP, because it uses four drugs consisting of cyclophosphamide, doxorubicin, vincristine, and prednisone, plus the monoclonal antibody rituximab.

Chemotherapy drugs work by slowing the ability of cancer cells to reproduce. R-CHOP chemotherapy is given every 3 weeks for approximately 4 months.


Radiation therapy or radiotherapy aims to kill cancer cells and inhibit their growth and spread. This therapy uses high-intensity X-ray exposure to kill cancer cells.

Radiotherapy is often used together with chemotherapy to maximize the effectiveness of treatment.


Immunotherapy is done to increase the body's immunity to be more effective against cancer. To treat DLBCL, this therapy is carried out using the drug rituximab which is specifically targeted at B lymphocyte cells.

However, these drugs can affect the work of the heart, so they are not recommended for people with heart disease. In addition, treatment can also be done with a combination of R-CHOP and radiation therapy.

Although the growth is classified as aggressive, diffuse large B-cell lymphoma tends to respond well to treatment so that the cure rate is also high.

It is not easy when you are diagnosed with DLBCL or other cancers. Therefore, there are several ways that you can do to deal with this condition, namely:

  • Learn more about diffuse large B-cell lymphoma.
  • Make sure you have the support of those around you, including your closest family and friends.
  • Determine the life goals you want to achieve.
  • Take time for yourself and fill it with activities you enjoy.
  • Stay active to keep your body he althy and fit.

In addition, you are also encouraged to adopt a he althy lifestyle by eating a balanced nutritious diet, exercising regularly, and getting enough rest time.

Seeing the dangers that can be caused, don't hesitate to immediately consult a doctor if you feel symptoms of diffuse large B-cell lymphoma such as swollen lymph nodes. This is important because DLBCL is curable if diagnosed and treated as early as possible.

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