Butorphanol - drug information

Table of contents:

Butorphanol - drug information
Butorphanol - drug information

Butorphanol is a medication to treat moderate to severe pain, such as muscle aches, migraine headaches, or pain from surgery. This drug can also be used as an anesthetic before and during surgery, and to relieve pain during labor

Butorphanol is an opioid pain reliever. This drug works by blocking pain stimuli that go to the brain and reducing the pain response in the brain, so the body does not feel pain.


Despite having many benefits, butorphanol can cause dependence if used for a long time. Therefore, the use of this drug must be in accordance with the doctor's advice.

Butorphanol trademark: -

What Is Butorphanol

Class Prescription drugs
Categories Opioid pain relievers
Benefits Relieves moderate to severe pain, as an anesthetic during surgery, and relieves pain during labor
Used by Adults and seniors
Butorphanol for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Butorphanol can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor.

Medicine form Injection and nasal spray

Warning Before Using Butorphanol

Butorphanol should not be used carelessly and must be in accordance with a doctor's prescription. Here are some things you need to pay attention to before using butorphanol:

  • Do not use butorphanol if you are allergic to this drug. Be sure to always tell your doctor about any allergies you have.
  • Do not drive a vehicle or operate equipment that requires vigilance while taking butorphanol, as this drug can cause dizziness and drowsiness.
  • Tell your doctor if you have severe asthma or other breathing problems, such as Chronic Obstructive Pulmonary Disease (COPD), or if you have symptoms of an intestinal obstruction, such as abdominal pain, abdominal distension, inability to pass stool or bowel movements wind, stomach swells, and nausea and vomiting.
  • Tell your doctor if you have or are currently addicted to alcohol or illegal drugs, or are taking opioid painkillers for a long time.
  • Tell your doctor if you have or have had liver disease, gallbladder disorders, pancreatitis, kidney disease, heart disease, hypertension, Addison's disease, kyphoscoliosis, enlarged prostate, hypothyroidism, head injury, brain tumor, seizures, psychosis, or sleep apnea.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking any other medicines, including supplements or herbal products.
  • Be careful using butorphanol in the elderly because the risk of side effects is greater.
  • Tell your doctor that you are taking butorphanol before undergoing any surgery or medical procedures, including dental surgery.
  • See your doctor immediately if you experience an allergic reaction, serious side effect, or overdose after using butorphanol.

Dosage and Instructions for Use of Butorphanol

The dose of butorphanol is determined based on the age, the patient's condition, and the body's response to the drug. Butorphanol can be given as a nasal spray or injection. The following is the dosage of butorphanol based on the form of the drug:

Nasal Spray Shape

Condition: Moderate to severe pain for migraine, muscle aches, or pain after surgery

  • Adults: 1–2 mg (1 spray in 1 nostril) when experiencing pain, can be repeated after 3-4 hours if needed.
  • Elderly: Initial dose is 1 mg, can be repeated after 90–120 minutes. Subsequent doses can be given at 6 hour intervals if needed.

Injection Form

Condition: Moderate to severe pain

  • Adults: 1–4 mg, dose can be repeated 3-4 hours if needed.

Condition: As an anesthetic before or during surgery

  • Adults: 2 mg before surgery and 0.5–1 during surgery.

Condition: Pain during labor

  • Adults: 1–2 mg at the start of labor, dose can be repeated after 4 hours if needed.

How to Use Butorphanol Correctly

Follow the doctor's advice and read the information on the medicine package before using butorphanol. Do not increase or decrease the dose without consulting your doctor, and do not use the drug for more than the recommended time.

Butorphanol injection should only be given by a doctor or medical officer under the supervision of a doctor. The doctor will inject butorphanol according to the patient's condition.

If you are using butorphanol in the form of a nasal spray, clean your nose and shake the bottle of this medicine before using it. Position your head slightly back. Close one hole with your finger, then spray the medicine into the other nostril.

If you still feel pain after 60–90 minutes, your doctor may suggest that you apply a second spray in the nostril that has not been sprayed.

After using butorphanol nasal spray, you are advised to lie down for a while to anticipate the effects, such as dizziness. Make sure there is enough time between one dose and the next (3–4 hours).

Keep the butorphanol nasal spray in the package. Place the medication in a cool, dry room. Keep the medicine away from direct sunlight and keep it out of reach of children.

Interaction of Butorphanol with Other Drugs

Interaction effects that can occur if butorphanol is used with certain drugs include:

  • Enhanced effect of butorphanol when used with phenothiazines, antihistamines, benzodiazepines, or barbiturate drugs
  • Increased risk of fatal side effects when used with monoamine oxidase inhibitors (MAOI)
  • Increased risk of hypertension if used with sumatriptan nasal spray
  • Increased risk of eye irritation when used with pancuronium
  • Decreased butorphanol levels when used with oxymetazoline nasal spray

Side Effects and Dangers of Butorphanol

Side effects that may occur after using butorphanol are:

  • Nausea
  • Vomiting
  • Sleepy
  • Dizziness or headache
  • Dry mouth
  • Skin feels warm and red
  • Blurred vision
  • Constipation
  • Irritation of the nose
  • Difficulty sleeping
  • Sweat more

Check with your doctor if the above complaints don't subside or are getting worse. See your doctor immediately if you experience an allergic reaction or more serious side effects, such as:

  • Anxiety
  • Hallucinations
  • Shortness of breath or heavy breathing
  • Rapid or irregular heartbeat (arrhythmia)
  • severe stomach ache
  • Difficulty urinating
  • No appetite
  • Exhaustion
  • Dizzy until you want to faint
  • Seizure