Phenothiazine - drug information

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Phenothiazine - drug information
Phenothiazine - drug information

Phenothiazines or phenothiazines are a class of drugs used to treat mental disorders, such as schizophrenia and psychotic disorders. Some of this class of drugs can also be used to treat other conditions, such as nausea and vomiting and hiccups

Phenothiazine is a typical or first-generation antipsychotic drug. Drugs in this class generally work by blocking dopamine receptors in the brain. By doing so, this drug can reduce the effects of excessive dopamine work, such as psychotic symptoms such as hallucinations and delusions, or anxiety.

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Although the exact mode of action is not known, this drug can also be used to treat some non-psychotic symptoms, such as severe nausea, vomiting, or hiccups. In fact, one of the phenothiazine drugs called promethazine is not used as an antipsychotic at all.

Warning Before Using Phenothiazine

Phenothiazine should not be used carelessly. Follow the doctor's recommendations and advice while undergoing treatment with this drug. Before taking phenothiazine, there are several things you should pay attention to, including:

  • Do not use phenothiazine if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements or herbal products. Be sure to tell your doctor if you are taking any medications, especially other antipsychotic medications, antidepressants, antiarrhythmic drugs, or antifungal medications.
  • Tell your doctor if you have or are currently suffering from difficulty urinating, glaucoma, heart disease, stomach ulcers, liver disease, lung disease, blood disorders, breast cancer, seizures, stroke, pheochromocytoma, kidney disease, Parkinson's disease, or Reye's Syndrome.
  • Do not consume alcoholic beverages while undergoing treatment with phenothiazines because it can exacerbate side effects.
  • Tell your doctor that you are taking phenothiazine if you have any medical tests, such as an electrocardiogram (ECG), gonadorelin test, metyrapone test, urine bilirubin test, or a test for phenylketonuria.
  • Do not drive a vehicle or perform activities that require alertness while taking phenothiazine, as this drug can cause blurred vision, drowsiness, or dizziness.
  • Tell your doctor that you are taking phenothiazine if you plan to have surgery or certain medical procedures, including dental surgery.
  • Limit or avoid activities in direct sunlight for a long time while undergoing treatment with phenothiazine, because this drug can make the skin more sensitive to sunlight.
  • Phenothiazines can reduce your ability to sweat, which can lead to hyperthermia. Avoid or limit activities in hot weather or in direct sunlight.
  • See your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking phenothiazine.

Side Effects and Dangers of Phenothiazine

There are several side effects that can potentially arise from the use of phenothiazine, including:

  • Urine turns dark in color
  • Sleepy
  • Dizzy
  • Low blood pressure
  • Constipation
  • Sweat less
  • Dry mouth
  • Stuffy nose
  • Blurred vision or sensitivity to light

Do an examination to the doctor if the side effects above do not subside. Immediately see a doctor if an allergic reaction occurs to the drug which is characterized by the appearance of an itchy and swollen rash, swollen eyes and lips, or difficulty breathing.

In addition, you should also go to the doctor immediately if you experience more serious side effects, such as:

  • I can't move my eyes
  • Eyes blinking uncontrollably
  • Lips that are pursed and stiff
  • Tension in the muscles of the face, neck, arms, body, or legs
  • Difficulty breathing, speaking, or swallowing
  • Loss of balance
  • Facial, arm and leg muscles move uncontrollably
  • Face becomes expressionless
  • Stiff arm or leg
  • Fingers shaking
  • Fainted

Types, Trademarks and Dosage of Phenothiazine

Phenothiazine types and trademarks vary. The dose of phenothiazine given depends on the type and form of the drug, as well as the age, and condition of the patient. Here are the details:


Trademarks: Cepezet 50, Cepezet 100, Chlorpromazine HCL, Chlorpromazine Hydrochloride, Chlopromazine, Promactil

To find out the dosage and further information about this drug, please visit the Chlorpromazine drug page.


Trademark: -

Condition: Anxiety (agitation)

Forms of drinking drugs

  • Adults: 100–200 mg 4 times a day
  • Elderly: The initial dose is 25 mg, 4 times a day. May be increased to 50 mg, 4 times daily, if needed.


Trademark: Sikzonoate

To find out the dosage and more information about this drug, please visit the Fluphenazine drug page.


Trademark: -

Condition: Resistant schizophrenia and severe schizophrenia

Injectable form

  • Adult: Initial dose is 25 mg. Administration of the drug can be repeated after 30–60 minutes if necessary. The maximum dose is 200 mg per day.

Forms of drinking drugs

  • Adults: Initial dose is 25–50 mg, 3 times a day. The dose can be increased up to 100–400 mg per day.


Trademark: -

To find out the dosage and more information about this drug, please open the drug Perphenazine.


Trademark: -

To find out the dosage and further information about this drug, please refer to the length of the drug Prochlorperazine.


Trademark: -

Condition: Schizophrenia

Forms of drinking drugs

  • Adults: Initial dose 50–100 mg. The dose can be increased gradually according to the patient's response and tolerability. Usual dosage range is 200–800 mg, 2–4 times daily. The maximum dose is 800 mg per day.


Trademarks: Stelosi, Stelosi 5, Stelazine, Trizine 5, Trifluoperazine HCL, Trifluoperazine Hydrochloride

To find out the dosage and further information about this drug, please refer to Trifluoperazine.


Trademarks: Bufagan Expectorant, Erpha Allergil, Gidadryl, Guamin, Halfilyn, Mucozine, Mezinex, Metagan Expectorant, Nufapreg, Prome, Promedex, Promethazine, Phenerica, Prozine Exprectorant, Winasal, Zenirex

To find out the dosage and further information about this drug, please refer to Promethazine for a long time.

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