Tranylcypromine - Benefits, dosage and side effects

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Tranylcypromine - Benefits, dosage and side effects
Tranylcypromine - Benefits, dosage and side effects

Tranylcypromine is a drug used to relieve or treat major depression. This drug is usually prescribed to patients whose depression is not helped by other drugs

Tranylcypromine is an antidepressant that belongs to the monoamine oxidase inhibitors (MAOI) class of drugs. Tranylcypromine works by balancing the amount of natural brain chemicals (neurotransmitters) that play a role in maintaining mental balance. In this way, this drug can improve mood and create positive feelings.

Tranylcypromine - allodokter
Tranylcypromine - allodokter

Tranylcypromine trademark: -

What is Tranylcypromine

Class Prescription drugs
Categories MAOI-type antidepressants
Benefits Treating major depression
Consumed by Adult
Tranylcypromine for pregnant and lactating women Category B: Animal studies have not shown any risk to the fetus, but there have been no controlled studies in pregnant women.

Tranylcypromine can be absorbed into breast milk. If you are breastfeeding, do not take this medicine before consulting your doctor.

Medicine form Tablets

Warning Before Taking Tranylcypromine

Tranylcypromine should only be taken according to a doctor's prescription. Here are some things to watch out for before using tranylcypromine:

  • Tell your doctor about any allergies you have. Tranylcypromine should not be used by patients allergic to this drug.
  • Tell your doctor if you have or have had pheochromocytoma, stroke, hypertension, chest pain, heart attack, heart failure, diabetes, frequent or severe headaches, schizophrenia, liver or kidney disease, bipolar disorder, seizures, hyperthyroidism, or Parkinson's disease.
  • Tell your doctor if you or a member of your family has or are currently suffering from angle-closure glaucoma.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are on medication with certain supplements, herbal products, or other medications.
  • Tell your doctor that you are taking tranylcypromine if you plan to have surgery or medical procedures that use contrast, such as a CT scan with contrast
  • Do not drive a vehicle or use machinery with a high risk of accident after taking tranylcypromine, because this drug can cause drowsiness or dizziness
  • Do not consume alcoholic beverages while on treatment with tranylcypromine, as this can increase the risk of side effects.
  • Go to the doctor immediately if there is an allergic reaction to the drug, overdose, or severe side effects.

Dosage and Instructions for Use of Tranylcypromine

Time of consumption and dose of tranylcypromine must be in accordance with the doctor's instructions. The dose of tranylcypromine will be adjusted according to the patient's condition and response to treatment. The following are common doses of tranylcypromine for major depressive conditions:

  • Initial dose: 10 mg in the morning and 10 mg at 12:00–18:00.
  • Advanced dose: 10 mg in the morning and 20 mg at 12:00–18:00, the dose is increased after a week of using the drug, if the expected treatment results are not achieved.
  • Alternative dose:10 mg in the morning, 10 mg at 12 noon, and the last 10 mg maximum at 18:00.
  • Maintenance dose: the dose is reduced by 10 mg per day with an interval of a few days, after the expected results are achieved and stabilized for some time.

How to Take Tranylcypromine Correctly

Consume tranylcypromine according to the doctor's recommendations and read the instructions for use on the packaging. Do not reduce or increase the dose of the drug without the doctor's instructions.

Tranylcypromine can be taken before or after meals. Be sure to take tranylcypromine at the same time each day, so that the drug can work optimally. Do not stop using the drug, except on the doctor's instructions.

If you forget to take tranylcypromine, take it immediately if the interval between the next consumption is not too close. When it's close, ignore it and don't double the next dose.

While undergoing treatment with tranylcypromine, follow the schedule of control and blood tests given by the doctor. This is done to monitor your condition and reduce the risk of side effects or overdose.

In addition to taking antidepressant drugs, lifestyle changes should also be made to optimize treatment for major depression. Regular exercise, eating a he althy diet, and getting enough sleep can increase daily energy, promote a happy mood, and reduce mood swings.

Store tranylcypromine in a closed container in a dry and cool place away from sun exposure. Keep this medicine out of reach of children.

Tranylcypromine Interactions with Other Drugs

The following are some of the effects of drug interactions that can occur if tranylcypromine is used with certain drugs or drug classes:

  • Reduced therapeutic effect of guanethidine
  • Increased blood sugar-lowering effect when used with oral antidiabetics and insulin
  • Increasing the effect of anticholinergic drugs for Parkinson's disease or narcotic analgesics
  • Enhanced effect of pethidine, blood pressure lowering drugs, nefopam, or dextromethorphan
  • Increased risk of hyperactivity when used with reserpine
  • Increased risk of central nervous system excitation when used with methyldopa
  • Increased risk of seizures when used with metrizamide
  • Increased risk of motor nerve disease when used with L-trytophan
  • Increased risk of developing severe hypertension if used with indirect acting sympathomimetic amines, such as amphetamines, fenfluramine, anti-obesity drugs, ephedrine, phenylpropanolamine, levodopa, or dopamine
  • Increased risk of high blood pressure if used with buspirone or bupropion
  • Increased risk of overdose when used with other MAOIs
  • Increased risk of hypertension and central nervous system excitation when used with tricyclic antidepressants
  • Increased risk of serotonin syndrome with fluvoxamine
  • Increased risk of severe side effects when used with SSRI or SNRI antidepressants

In addition, the risk of side effects may increase if tranylcypromine is taken with alcoholic beverages or foods with high levels of tyramine, such as cheese, sausage, ham, pickles, kimchi, or soy bean products, such as tempeh and tofu.

Side Effects and Dangers of Tranylcypromine

Side effects that can occur after taking tranylcypromine may vary, such as dizziness, drowsiness, sleep disturbances, constipation, fatigue, dry mouth, or feeling weak. Call your doctor if these side effects get worse or don't get better.

Consult a doctor if there are more serious side effects, such as:

  • Changes in mood or mental state, such as confusion or restlessness
  • Suicidal ideation
  • Stiff muscles
  • Changes in libido
  • Tremor
  • Shiver
  • Swollen feet or ankles
  • Unusual weight gain
  • Swollen, painful, or red eyes
  • Blurred or double vision
  • Jaundice, dark urine, stomach pain, and persistent nausea or vomiting
  • Seizure
  • Fainted

Go to the doctor immediately if there is an allergic reaction to the drug or severe side effects that need to be treated immediately, such as:

  • Hypertensive crisis (systolic blood pressure above 180 mmHg), which may be accompanied by severe or frequent headaches, fast, slow, or irregular heartbeat, chest pain, neck stiffness or pain, nausea or vomiting, moist skin, excessive sweating, dilated pupils, or sensitivity to light
  • Serotonergic syndrome, which is characterized by palpitations, loss of body coordination, hallucinations, a feeling of extreme spinning or floating in the head, muscle twitching, fever, restlessness and restlessness, and persistent nausea, vomiting, or diarrhea