Mivacurium - Benefits, dosage and side effects

2023 Author: Autumn Gilbert | [email protected]. Last modified: 2023-11-27 07:39

Mivacurium is a medication that is used to relax muscles during surgery or during the installation of a breathing apparatus. This medicine should only be given by a doctor in a hospital

Mivacurium is a fast acting muscle relaxant. This drug works by blocking acetylcholine, which is a signaling chemical that helps stimulate muscles to contract. Thus, this drug can cause temporary muscle paralysis.

Mivacurium trademark: -

What is Mivacurium

Class	Prescription drugs
Categories	Neuromuscular blocking drugs (NMBDs) or non-depolarizing muscle relaxants
Benefits	Sooth muscles
Used by	Adults and children
Mivacurium for pregnant and lactating women	Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk to the fetus. It is not yet known whether mivacurium can be absorbed into breast milk or not. If you are breastfeeding, do not use this medication without telling your doctor first.
Medicine form	Inject

Warning Before Using Mivacurium

Before using mivacurium, you need to pay attention to the following points:

• Do not use mivacurium if you are allergic to this drug. Tell your doctor about any allergies you have.
• Tell your doctor if you have heart disease, impaired liver or kidney function, and myasthenia gravis.
• Tell your doctor if you have a pseudocholinesterase deficiency, which can be characterized by a history of paralysis or muscle weakness that persists after surgery.
• Tell your doctor about any medications, supplements or herbal products you are currently taking.
• Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.

Dosage and Instructions for Use Mivacurium

Mivacurium will be given by injection through a vein (intravenous / IV) by a doctor or medical officer under the supervision of a doctor. The following are general doses of mivacurium based on the purpose of treatment:

Purpose: Addition to general anesthesia

• Adults: Initial dose 70–250 mcg/kgBB. The maintenance dose is 100 mcg/kg every 15 minutes.
• Children aged 2–6 months: Initial dose is 150 mcg/kgBB. The maintenance dose is 100 mcg/kg every 6–9 minutes.
• Children aged 7 months to 12 years: Initial dose is 200 mcg/kgBB. The maintenance dose is 100 mcg/kg every 6–9 minutes.

Goal: Neuromuscular block

• Adult: Infusion at a rate of 8–10 mcg/kgBB per minute.
• Children aged 2 months to 12 years: 11–14 mcg/kgBW per minute via IV.

Destination: Endotracheal intubation

• Adults: Initial dose of 150 mcg/kgBW, followed by a dose of 100 mcg/kgBW 30 seconds thereafter.
• Children aged 2–12 years: 200 mg/kgBB.

How to Use Mivacurium Correctly

Mivacurium will be given directly by a doctor or medical officer under the supervision of a doctor. The medicine will be injected directly into a vein (intravenous/IV) or through an IV, as recommended by the doctor.

This drug can only be used in hospitals. During the injection of mivacurium, the doctor will closely monitor the patient.

Mivacurium Interaction with Other Drugs

The effects of drug interactions that can occur if mivacurium is used together with other drugs are:

• Increased effectiveness of mivacurium when used with aminoglycosides, calcium antagonists, tetracyclines, clindamycin, quinidine, ketamine, opioid analgesics, metoclopramide, or vancomycin
• Decreased effectiveness of mivacurium when used with carbamazepine, phenytoin, corticosteroids, calcium, or theophylline

Side Effects and Dangers of Mivacurium

Some of the side effects that may occur after using mivacurium are:

• Redness and burning sensation in the face, neck, or chest (flushing)
• Pain at the injection site
• Mild hypotension
• Shortness of breath or wheezing
• heart rate fast or slow

Report to the doctor if the above side effects do not subside or get worse. You should also tell your doctor right away if you have an allergic reaction to medication or an irregular heartbeat after taking mivacurium.