Danazol - Benefits, dosage and side effects

2023 Author: Autumn Gilbert | [email protected]. Last modified: 2023-11-27 07:39

Danazol is a drug to treat pelvic pain or fertility problems due to endometriosis. This medicine can also be used to relieve symptoms of fibrocystic breast lumps

Danazol is a hormonal drug. This drug will produce effects similar to natural androgen hormones in the body. To treat pelvic pain and fertility problems due to endometriosis, this drug will inhibit the formation and release of hormones from the adrenal glands and ovaries.

In addition, this drug can also increase the production of C1 esterase inhibitors, which are special proteins that are low in numbers in people with hereditary angioedema. This way of working will reduce the risk of recurrence of complaints, such as swelling in the abdomen, arms, legs, and respiratory tract, due to this condition.

Danazol Trademark: Azol 200

What is Danazol

Class	Prescription drugs
Categories	Androgenic hormones
Benefits	Treats endometriosis, relieves complaints of fibrocystic breast disease, and prevents recurrence of angioedema symptoms
Consumed by	Adult
Danazol for pregnant and lactating women	Category X: Studies in experimental animals and humans have shown fetal abnormalities or a risk to the fetus. Drugs in this category should not be given to women who are or may become pregnant. It is not known whether danazol can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.
Medicine form	Capsule

Warning Before Taking Danazol

This drug must be used according to the doctor's prescription and advice. Before taking this drug, you need to pay attention to the following things:

• Do not take danazol if you are allergic to this drug. Tell your doctor about any allergies you have.
• Tell your doctor if you have porphyria, vaginal bleeding of unknown cause, heart failure, liver failure, or kidney failure. Danazol should not be used by this patient.
• Tell your doctor if you have epilepsy, migraines, diabetes, hypoparathyroidism, breast cancer, uterine cancer, heart disease, hypertension, or have had a stroke or blood clotting disorder.
• Tell your doctor if you are taking any medications, supplements or herbal products.
• Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Danazol should not be taken by pregnant women.
• Notify your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking danazol.

Dosage and Instructions for Use of Danazol

The dose of danazol will be determined by the doctor according to the condition you want to treat. In general, the following are the dosages of danazol:

• Condition: EndometriosisFor mild endometriosis, the dose is 200–400 mg per day, divided into 2 divided doses. For moderate to severe endometriosis, the dose is 800 mg per day, divided into 2 doses.

• Condition: Fibrocystic breast lumpThe dose is 100–400 mg per day, divided into 2 doses.

• Condition: Hereditary angioedemaInitial dose 200 mg, 2-3 times a day. Then the doctor can adjust the dose according to the needs and condition of the patient.

How to Take Danazol Correctly

Follow the doctor's advice and read the information on the medicine package before taking danazol. Do not reduce or increase the dose without consulting your doctor first.

Danazol can be taken before or after meals. Try to take danazol at the same time every day for maximum treatment. Keep taking this medicine even if you feel well. Do not stop taking this medicine without consulting your doctor.

If danazol is used to treat endometriosis, then treatment is started during the menstrual period. Generally, endometriosis treatment takes 3–9 months. Meanwhile, to prevent angioedema this drug may need to be consumed in the long term

If you forget to take danazol, it is recommended to take it immediately if the gap between the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

During treatment with danazol, your doctor may ask you to undergo regular he alth checks, including liver and kidney function tests, blood pressure, cholesterol levels, and blood sugar. Follow the examination schedule given by the doctor.

Store danazol in a dry place and avoid direct sunlight. Keep this medicine out of reach of children.

Interaction of Danazol with Other Drugs

The following are some of the effects of drug interactions that can occur when danazol is used with other drugs:

• Increased blood levels of carbamazepine, ciclosporin, or tacrolimus
• Increased risk of myopathy and rhabdomyolysis when used with simvastatin, atorvastatin, or lovastatin
• Increased risk of insulin resistance
• Increased risk of bleeding when used with warfarin

Side Effects and Dangers of Danazol

Some of the side effects that can occur after taking danazol are:

• Pimples appear
• weight gain
• hair growth on the face, neck, chest, or stomach (hirsutism)
• Warmness and heat in the face, neck, or chest (flushing)
• bust size decreases
• Vagina dry or irritated
• Restless or nervous
• Menstrual disorders, including no menstruation, spotting, or changes in the menstrual cycle

Consult your doctor if the side effects above do not subside immediately or are getting worse. You need to see a doctor immediately if you experience an allergic reaction to a drug or a more serious side effect, such as:

• Swelling of the arms or legs accompanied by redness or warmth
• Numbness or weakness on one side of the body
• Jaundice, dark urine, upper right abdominal pain, or no appetite
• Increased intracranial pressure (inside the brain) which can be characterized by severe headache, vomiting, or blurred vision