Epoetin Beta - Benefits, dosage and side effects

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Epoetin Beta - Benefits, dosage and side effects
Epoetin Beta - Benefits, dosage and side effects
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Epoetin beta is a drug to treat anemia due to chronic kidney failure or patients suffering from anemia of prematurity. Epoetin beta can also increase blood cell production in preparation for surgery

Epoetin beta works similar to a natural hormone in the body whose amount and production decreases in people with kidney failure. This drug will trigger the production and formation of red blood cells in the bone marrow.

Epoetin beta - alodokter

Epoetin beta trademark: Mircera, Recormon

What is Epoetin Beta

Class Prescription drugs
Categories Erythropoiesis-stimulating agents (ESA)
Benefits Treating anemia in patients with chronic kidney failure
Used by Adults and children
Epoetin beta for pregnant and lactating mothers Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Epoetin beta is not yet known whether it can be absorbed through breast milk or not. If you are breastfeeding, do not use this medication without telling your doctor.

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Warning Before Using Epoetin Beta

Epoetin beta should only be used according to a doctor's prescription. There are several things that need to be considered before using epoetin beta, namely:

  • Tell your doctor about any allergies you have. Epoetin beta should not be given to patients who are allergic to any of the ingredients in this drug.
  • Tell your doctor if you have uncontrolled hypertension. Epoetin beta should not be given to patients with this condition.
  • Tell your doctor if you have or have had seizures, epilepsy, liver failure, heart disease, stroke, deep vein thrombosis (DVT), pulmonary embolism, thrombocytosis, or anemia due to folic acid deficiency,
  • Tell your doctor if you have recently had heart bypass surgery.
  • Follow the control schedule given by the doctor. During treatment with epoetin beta you will need to undergo regular blood tests, so that your condition is monitored.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • During treatment your condition will be monitored by a doctor. Report to your doctor if you experience an allergic drug reaction, serious side effect, or overdose, after using epoetin beta.

Dosage and Rules for Using Epoetin Beta

Epoetin beta will be given through a vein (intravenous/IV) or injected under the skin (subcutaneously/SC) by a doctor or medical officer under the supervision of a doctor.

The dose of epoetin beta will be determined by the doctor according to the goals of treatment and the condition experienced by the patient. In general, the following are the dosage details of epoetin beta:

Purpose: Treating anemia in patients with chronic kidney failure

  • SC injection dose: 60 units/kgBW per week, for 4 weeks.
  • IV injection dose: 40 units/kgBW 3 times a week, for 4 weeks.

Goal: Increase blood cell production in preparation for surgery

  • IV injection dose: 200–800 units/kgBW, 2 times a week, starting 4 weeks before surgery.
  • SC injection dose: 150–600 units/kgBW, 2 times a week, starting 4 weeks before surgery.

Purpose: Treating anemia of prematurity

  • SC injection dose: 250 units/kgBB 3 times a week. Treatment is carried out for 6 weeks.

How to Use Epoetin Beta Correctly

Epoetin beta should only be injected by a doctor or medical officer under the supervision of a doctor in a hospital. Follow the doctor's advice and recommendations while undergoing therapy with epoetin beta.

Make sure to carry out a medical check-up according to the schedule given by the doctor.

Do not stop taking epoetin beta treatment without consulting your doctor first. Stopping medication suddenly can make the condition more difficult to treat.

Please note, people with hypertension or kidney disorders need to undergo a diet or dose adjustment that will be determined by the doctor, so that blood pressure is more controlled. Controlled blood pressure can reduce the risk of side effects due to epoetin beta.

Interaction of Epoetin Beta with Other Drugs

There are several drug interaction effects that can occur when epoetin beta is used with certain drugs, namely:

  • Reduced effectiveness of ACE inhibitors or ARBs in lowering blood pressure and increasing the risk of hyperkalemia
  • Increased risk of dangerous blood clots when used with carfilzomib, lenalidomide, pomalidomide, or thalidomide

Side Effects and Dangers of Epoetin Beta

Side effects that can occur after taking epoetin beta include:

  • Headache
  • Body feels pain
  • Stuffy nose or sneezing
  • Fever, cough or chills
  • Vomiting
  • Diarrhea or constipation
  • Irritation at the injected area

Check with your doctor if the side effects above don't go away or get worse. Go to the doctor immediately if you experience an allergic reaction to the drug or serious side effects, such as:

  • High blood pressure
  • Anemia that is getting worse
  • Seizure
  • Heart failure, which can be characterized by symptoms such as shortness of breath, swelling in the legs, weight gain
  • Blood clots that if they block the arteries in the heart can cause a stroke

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