Remifentanil - Benefits, dosage and side effects

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Remifentanil - Benefits, dosage and side effects
Remifentanil - Benefits, dosage and side effects

Remifentanil is a painkiller that is used to initiate and maintain the anesthetic process. As part of the anesthetic process, this drug will be used with other drugs, such as propofol, midazolam, or thiopenthal

Remifentanil is an opioid painkiller that works by blocking the flow of pain signals in the brain, which in turn affects the body's response to pain. Remifentanil will be given by a doctor or medical officer at the hospital. This drug is available in injection dosage forms of 1 mg, 2 mg, and 5 mg.

Remifentanil - Alodokter

Remifentanil trademark: Remikaf

What is Remifentanil

Class Prescription drugs
Categories opioid painkillers
Benefits As painkillers in the process of anesthesia (anaesthesia)
Used by Adults and seniors
Remifentanil for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Remifentanil is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Medicine form Inject

Warning Before Using Remifentanil

Remifentanil should only be used in hospitals and will be given directly by a doctor. The following are some things to consider before using remifentanil:

  • Tell your doctor about any allergies you have. Remifentanil should not be given to patients who are allergic to this drug or to fentanyl.
  • Tell your doctor if you are or have recently been on treatment with monoamine oxidase inhibitors (MAOIs), such as selegiline. Remifentanil should not be given to patients who are currently or have recently been treated with this drug.
  • Remifentanil will be given in the hospital, follow the doctor's advice before, during, and after the injection. Monitoring of the patient's condition will be carried out periodically.
  • Tell your doctor if you have ever abused drugs or became addicted to alcohol.
  • Tell your doctor if you have chronic obstructive pulmonary disease (COPD), asthma, sleep apnea, heart disease, bradycardia, low blood pressure, benign enlargement of the prostate gland (BPH), inflammation of the pancreas, thyroid disease, seizures, disease liver, or kidney disease.
  • Tell your doctor if you have a condition that can increase intracranial pressure, such as a brain tumor or head injury.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Notify your doctor immediately if you experience an allergic reaction to the drug, a more serious side effect, or an overdose after taking remifentanil.

Dosage and Instructions for Use of Remifentanil

Remifentanil will be given by the doctor. The dose will be determined according to the conditions and the intended use of the drug. In general, the following are the dosages of remifentanil as a painkiller for the induction and maintenance of general anaesthesia:

  • The initial dose before intubation is 1mcg/kg/BB. The dose for induction of anesthesia is 0.5–1 mcg/kgBW per minute.
  • Maintenance dose during general anesthesia 0.25–0.5 mcg/kgBW per minute.
  • Additional doses to increase the analgesic effect during anesthesia can be given 0.5–1 mcg/kgBW every 2–5 minutes.

For elderly patients, remifentanil will be given starting at the lowest dose, then the dose can be increased if needed.

How to Use Remifentanil Correctly

Remifentanil injection will be given by a doctor or medical personnel under the supervision of a doctor at the hospital. Remifentanil will be injected directly through a vein (intravenous / IV).

The doctor will monitor the patient's breathing, blood pressure, oxygen level, and kidney function while taking remifentanil. Follow all doctor's recommendations before, during, or after remifentanil injection for maximum treatment effectiveness.

Interaction of Remifentanil with Other Drugs

The following are some possible interactions when taking remifentanil with other drugs:

  • Increased risk of hypotension, severe sedation, respiratory depression, coma, and even death if used with benzodiazepines, sedatives, antipsychotics, neuromuscular blocking drugs, or anticiolytics
  • Increased risk of serotonin syndrome if used with antidepressant drugs, such as monoamine oxidase inhibitors (MAOIs) or selective serotonin reuptake inhibitors (SSRIs)
  • Remifentanil's effectiveness decreases, even triggering withdrawal symptoms when used with other opioid painkillers, such as butorphanol, nalbuphine, or buprenorphine.

Side Effects and Dangers of Remifentanil

Some of the side effects that can occur after using remifentanil are:

  • Breath slows down
  • Slow or irregular heartbeat
  • Nausea or vomiting
  • Low or increased blood pressure
  • Shaking
  • Dizziness or severe tiredness
  • muscles feel stiff
  • Low blood pressure
  • Bile duct disorders

The doctor will monitor your condition before, during, and after the remifentanil injection. Report to your doctor if side effects persist or an allergic reaction occurs after taking remifentanil.

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