Gemcitabine - Benefits, dosage and side effects

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Gemcitabine - Benefits, dosage and side effects
Gemcitabine - Benefits, dosage and side effects
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Gemcitabine is a chemotherapy drug to treat several types of cancer, such as ovarian cancer, breast cancer, non-small cell lung cancer, or pancreatic cancer

This drug works by triggering the death of cancer cells. That way, the growth and development of cancer can be slowed or stopped. Gemcitabine will be administered in the hospital by a doctor or medical officer under the supervision of a doctor.

Gemcitabine - Alodokter

Gemcitabine trademarks: DBL Gemcitabine, Fonkogem, Gapoly, Gemcikal, Gemcitabine HCL, Gemhope, Gemtan, Gemtero, Getanosan, Gemzar, Kabigeta

What is Gemcitabine

Class Prescription drugs
Categories Chemotherapy drugs
Benefits Treating ovarian cancer, lung cancer, pancreatic cancer, or breast cancer
Used by Adult
Gemcitabine for Pregnant and Breastfeeding Mothers Category D: There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations. Gemcitabine is not known to absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor.
Medicine Form Powder for infusion

Warning Before Using Gemcitabine

Gemcitabine will be given by the doctor at the hospital. There are several things you should pay attention to before using gemcitabine, namely:

  • Tell your doctor about any allergies you have. Gemcitabine should not be given to patients who are allergic to this drug.
  • Tell your doctor if you have alcoholism, kidney disease, liver disease, or heart disease, such as an irregular heartbeat or heart failure.
  • Tell your doctor if you have or are currently undergoing radiotherapy.
  • Tell your doctor if you are taking any other medicines, including supplements or herbal products.
  • Tell your doctor that you are being treated with gemcitabine before undergoing certain medical procedures or surgery.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. This medicine should not be used by pregnant women or nursing mothers. Use effective contraception during treatment with gemcitabine up to 6 months after the last dose.
  • As much as possible, avoid close contact with people with infectious diseases that are easily contagious, such as the flu, while undergoing treatment with gemcitabine, because it can increase your risk of contracting it.
  • Consult your doctor if you plan to vaccinate while on treatment with gemcitabine.
  • Do not do things that require vigilance, such as driving a vehicle after using this medicine. This medicine may cause drowsiness and dizziness.
  • See your doctor immediately if you have an allergic reaction, serious side effects, or overdose, after using gemcitabine.

Dosage and Instructions for Use of Gemcitabine

The dose of gemcitabine given by the doctor depends on the patient's condition, body surface area (LPT), and the patient's body response to therapy. Gemcitabine will be given by infusion into a vein (intravenous/IV).

In general, the following is the dosage of gemcitabine according to the condition and body surface area:

Condition: Ovarian cancer

  • Treatment is combined with carboplatinThe dose is 1000 mg/m² LPT via infusion for 30 minutes on day 1 and day 8 in a 21-day cycle. The dose can be reduced in each follow-up cycle or depending on the patient's body response to treatment.

Condition: Non-small cell lung cancer

  • Single treatmentThe dose is 1000 mg/m²LPT, once a week via infusion for 30 minutes, administered for 3 weeks followed by a rest period of 1 week.

  • Treatment is combined with cisplatinThe dose is 1,000 mg/m²LPT, once a week by infusion for 30 minutes on days 1, 8, and 15 in a 28-day cycle. An alternative dose of 1,250 mg/m²LPT by infusion over 30 minutes on days 1 and 8 of a 21 day cycle.

Condition: Advanced bladder cancer

  • Treatment is combined with cisplatinThe dose is 1000 mg/m²LPT by infusion for 30 minutes on day 1, 8, and 15 in a 28 day cycle. The dose can be reduced in each follow-up cycle or depending on the patient's body response to treatment.

Condition: Pancreatic cancer

  • Single treatmentThe dose is 1000 mg/m² LPT, once a week, by infusion for 30 minutes. Treatment was carried out for 7 weeks, then followed by a rest period of 1 week. The dose is then given again every 1 week, for 3 consecutive weeks in a 4 week cycle.

Condition: Breast cancer

  • The treatment is combined with paclitaxelThe dose is 1,250 mg/m²LPT via infusion for 30 minutes on day 1 and day 8 in a 21 day cycle. The dose can be reduced in each follow-up cycle or depending on the patient's body's response to treatment. Prior to this therapy, patients are required to do blood tests to determine the number of granulocytes.

How to Use Gemcitabine Correctly

Gemcitabine will be given by a doctor or medical officer under the supervision of a doctor. This drug is given by infusion into a vein (intravenous/IV) for more than 30 minutes.

Notify the doctor if there is burning, pain or swelling in the infused area. If this medicine accidentally gets on the skin, clean the area immediately with soap and warm water.

During treatment with gemcitabine, the doctor will ask you to undergo regular blood tests, as well as kidney, liver and lung examinations.

Gemcitabine Interactions with Other Drugs

Some of the drug interactions that can occur if gemcitabine is used with certain drugs are:

  • Enhanced anticoagulant effect of warfarin
  • Increased risk of lung damage when used with bleomycin
  • Increased risk of infectious disease and reduced effectiveness of vaccines when used with live vaccines, such as yellow fever vaccine

Side Effects and Dangers of Gemcitabine

Here are some side effects that can occur after using gemcitabine:

  • Pain or swelling at the injection site
  • Nausea and vomiting
  • Diarrhea
  • Thrush
  • Sleepy
  • Muscle pain
  • Hair loss

Tell your doctor if your side effects don't subside or get worse. See a doctor immediately if you have an allergic reaction to the drug or a more serious side effect, such as:

  • Cough or shortness of breath
  • Dizziness, headache, feeling light-headed, or feeling faint
  • Swelling of the feet or hands
  • Numbness or tingling
  • Slow, fast, or irregular heartbeat
  • Jaundice, stomach pain, or dark urine
  • Infrequent urination or very little urine
  • chest pain
  • Weakness on one side of the body, severe headache, or slurred speech
  • Pale skin, fatigue, sore throat, fever, chills, and easy bruising
  • Confusion, mood disturbances, or seizures

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