Hydromorphone - Benefits, dosage and side effects

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Hydromorphone - Benefits, dosage and side effects
Hydromorphone - Benefits, dosage and side effects
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Hydromorphone or hydromorphone hydrochloride is a medication to relieve moderate to severe pain. This drug should not be used carelessly and must be in accordance with a doctor's prescription.

Hydromorphone is an opioid painkiller that works by blocking the flow of pain signals in nerve cells to the brain, which in turn affects the body's response to pain. This medication is not intended to relieve mild pain.

Hydromorphone - Alodokter

Hydromorphone trademark: Jurnista

What is Hydromorphone

Class Prescription drugs
Categories opioid painkillers
Benefits Relieves moderate to severe pain
Used by Adults and seniors
Hydromorphone for pregnant and lactating mothers Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Hydromorphone can be absorbed into breast milk. If you are breastfeeding do not use this medicine without telling your doctor.

Medicine form Tablets, slow-release tablets, syrups, injections and suppositories

Warning Before Using Hydromorphone

Hydromorphone should not be used carelessly and must be in accordance with a doctor's prescription. The following are things you need to pay attention to before using hydromorphone:

  • Tell your doctor about any allergies you have. Hydromorphone should not be used by patients allergic to this drug.
  • Tell your doctor if you have or have had asthma, intestinal obstruction, paralytic ileus, brain tumor, liver disease, kidney disease, gallbladder disease, thyroid disease, chronic obstructive pulmonary disease (COPD), benign prostate enlargement (BPH), hypotension, or Addison's disease.
  • Tell your doctor if you have ever had a head injury, sleep apnea, alcoholism, difficulty urinating, pancreatitis, drug abuse, seizures, or mental disorders.
  • Do not use hydromorphone if you have taken monoamine oxidase inhibitors (MAOI) in the past 14 days.
  • Tell your doctor if you are taking any medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor that you are taking hydromorphone before any surgery, including dental surgery.
  • Do not drive a vehicle or do activities that require alertness after taking hydromorphone, as this medicine can cause dizziness or drowsiness.
  • See your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking hydromorphone.

Dosage and Instructions for Use of Hydromorphone

The dose of hydromorphone is determined by the doctor based on the age, condition of the patient, and the body's response to the drug. In general, the following are the dosages of hydromorphone for moderate to severe pain based on the form of the drug:

  • Oral form (tablets and syrup)

    Tablet dosage is 2-4 mg, every 4-6 hours or as needed. The dosage of syrup is 2.5–10 mg, every 3–6 hours.

  • Injectable form

    The dose is 1-2 mg, by IM/SC injection, every 2-3 hours. Alternative dose 0.2–1 mg, every 2–3 hours by slow IV injection over at least 2–3 minutes.

  • Suppository form

    The dose is 3 mg, every 6–8 hours or as needed.

For elderly patients, hydromorphone will be given starting at the lowest dose, then the dose can be increased if needed.

How to Use Hydromorphone Correctly

Follow the doctor's advice and read the information on the packaging label before using hydromorphone. Use hydromorphone according to the prescribed dose.

Hydromorphone tablets can be taken before or after meals. Take hydromorphone tablets with a glass of water, do not split, crush, or chew the medicine because it can increase side effects.

For hydromorphone syrup, shake the bottle of hydromorphone before drinking. Use the measuring spoon that comes in the package to get the exact dose, and do not use a regular tablespoon because the size of the dose can be different.

Hydromorphone injection should only be given by a doctor or medical officer under the supervision of a doctor. Injections can be given through a muscle (intramuscular/IM), a vein (intravenous/IV) or under the skin (subcutaneous/SC).

For hydromorphone suppositories, wash your hands before and after using this medicine. Remove the packaging and wet the medicine with cold water. Position yourself lying on your side, then insert the suppository into your rectum with your finger.

Make sure there is enough time between one dose and the next. If you forget to use hydromorphone, use it immediately if the break with the next schedule of use is not too close. If it's close, ignore it and don't double the dose.

Do not increase or decrease the dose without consulting your doctor first. This drug can cause dependence or overdose if used in excess. Do not stop using the drug suddenly because hydromorphone can cause withdrawal symptoms, especially for patients who have been using hydromorphone for a long time.

Store hydromorphone in a closed place in a cool temperature. Protect this medication from exposure to direct sunlight. Keep out of reach of children.

Hydromorphone Interaction with Other Drugs

Some of the following drug interactions may occur if hydromorphone is used with certain drugs:

  • Increased risk of hydromorphone poisoning which can cause hypotension, high body temperature (hyperpyrexia), deep drowsiness (somnolence), and even death if used with monoamine oxidase inhibitors (MAOI) drugs, such as isocarbixazid or linezolid
  • Decreased effectiveness of hydromorphone when used with opioid antagonist drugs, such as pentazocine
  • Increased risk of fatal side effects, such as seizures, coma, and even death if used with sedatives, antipsychotics, neuromuscular blocking drugs, or antihistamines

In addition, if hydromorphone is used with alcohol, it can increase the risk of fatal side effects.

Side Effects and Dangers of Hydromorphone

Some of the side effects that can occur after using hydromorphone are:

  • Drowsiness, tiredness, dizziness, or feeling light-headed
  • Headache
  • Constipation
  • Nausea or vomiting
  • Dry mouth
  • Excessive sweating
  • Redness, pain, and irritation at the injection site (especially for injection preparations)

Check with your doctor if the side effects above don't get better or get worse. Go to the doctor immediately if you experience an allergic reaction to the drug or serious side effects, such as:

  • Heavily dizzy until he passed out
  • Shortness of breath
  • Sleep apnea
  • Heart rate slows down
  • Confusion, irritability, or hallucinations
  • Difficulty urinating
  • severe stomach ache
  • No appetite, unusually tired, or drastic weight loss
  • Seizure
  • very deep sleep

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