Exemestane - Benefits, dosage and side effects

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Exemestane - Benefits, dosage and side effects
Exemestane - Benefits, dosage and side effects

Exemestane is a drug to treat breast cancer. One of them is ER-positive breast cancer (estrogen receptor-positive) in postmenopausal women. Exemestane can also be given to breast cancer patients who are already undergoing treatment with tamoxifen

Estrogen receptor positive (ER positive) breast cancer is a type of breast cancer whose growth is triggered by the hormone estrogen. Exemestane works by lowering the levels of estrogen produced by the body. That way, the growth of estrogen receptor positive cancer cells can be inhibited and stopped.

Exemestane - Alodokter

Exemestane trademark: Aromasin, Axeltane, Nateran

What is Exemestane

Class Prescription drugs
Categories Aromatase inhibitor class of anticancer drugs
Benefits Treating breast cancer
Consumed by Adult
Exemestane for pregnant and lactating women Category X: Studies in experimental animals and humans have shown fetal abnormalities or a risk to the fetus.

This medicine should not be taken by women who are or have the possibility of becoming pregnant.

Exemestane is not known to be absorbed into breast milk or not. Breastfeeding mothers should not take this drug.

Medicine form Tablets

Warning Before Taking Exemestane

Exemestane should not be used carelessly and must be in accordance with a doctor's prescription. There are several things that need to be considered before taking this drug, including:

  • Tell your doctor about any allergies you have. Exemestane should not be given to patients who are allergic to this drug.
  • Tell your doctor if you are still having your period, are pregnant, or are planning a pregnancy. Exemestane should not be given in these conditions. Use effective contraception as recommended by the doctor while undergoing treatment with this drug.
  • Tell your doctor if you are breastfeeding. You should not breastfeed while on treatment with exemestane, until 1 month after completion of therapy.
  • Tell your doctor if you are taking hormone therapy using estrogen or are using hormonal contraceptives, such as birth control pills, implants, or birth control injections.
  • Tell your doctor if you have or are currently suffering from kidney disease, liver disease, osteoporosis, osteopenia, high cholesterol, stroke, hypertension, or heart disease, such as a heart attack or heart failure.
  • Do not drive a vehicle or do activities that require alertness after taking exemestane, as this drug can cause dizziness and fatigue.
  • Tell your doctor that you are taking exemestane if you plan to have surgery, special medical procedures, or dental surgery.
  • Tell your doctor if you are taking certain medications, supplements or herbal products,
  • See your doctor immediately if you experience an allergic drug reaction, overdose, or serious side effects after taking exemestane.

Dosage and Instructions for Use of Exemestane

Exemestane will be given by the doctor. The dose and duration of treatment will be determined based on the patient's condition, the patient's condition, the patient's response to treatment, and other drugs that the patient is currently taking.

In patients with early-stage ER positive breast cancer who have gone through menopause and have been on tamoxifen for 2–3 years, the dose of exemestane is 25 mg, once a day, taken for 5 years.

Meanwhile, in patients with advanced breast cancer who have gone through menopause, the dose of exemestane is 25 mg, once a day, until the condition improves.

How to Take Exemestane Correctly

Follow the doctor's advice and read the information on the drug packaging label before taking exemestane. Do not reduce or increase the dose, and do not use the drug for more than the recommended time.

Exemestane tablets should be taken after meals. Swallow the tablet whole with a glass of water. It is recommended to take exemestane regularly at the same time every day for maximum treatment effect.

Before and during treatment with exemestane, you need to undergo an examination to see the level of vitamin D in the body. Your doctor may also recommend that you take vitamin D while on treatment with exemestane. Take vitamin D according to the doctor's prescription.

If you forget to take exemestane, take it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

Do regular check-ups according to the schedule given by the doctor, so that your condition can be monitored properly.

Store exemestane tablets in a closed container in a cool room. Protect this medicine from direct sunlight, and keep the medicine out of reach of children.

Exemestane Interaction with Other Drugs

The use of exemestane with other drugs can cause drug interactions, such as:

  • Reduced blood levels of exemestane when used with phenytoin, carbamazepine, or rifampicin
  • The effectiveness of the drug exemestane decreases when used with hormonal drugs containing estrogen or the herbal medicine St John's wort

Side Effects and Dangers of Exemestane

Some of the possible side effects after taking exemestane are:

  • Hot flashes or sensations of heat and heat
  • Nausea
  • Hair loss
  • Headache, dizziness, or tiredness
  • Appetite increases
  • Muscle pain
  • Difficulty sleeping

Do an examination to the doctor if the side effects above don't go away or get worse. Immediately see a doctor if there is an allergic reaction to the drug or a more serious side effect, such as:

  • Chest pain or pressure in your chest, difficulty breathing, or coughing up blood
  • Severe dizziness, confusion, until fainting
  • bone pain or fracture
  • Swelling in the hands or feet, warmth or pain in the feet
  • Sudden weakness or numbness, blurred vision, or speech impediments
  • Dark urine, severe tiredness, yellowish skin or eyes (jaundice)
  • Anxiety or depression
  • Bleeding from vagina

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