Everolimus - Benefits, dosage and side effects

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Everolimus - Benefits, dosage and side effects
Everolimus - Benefits, dosage and side effects
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Everolimus is a drug to prevent body rejection reactions after organ transplantation. In addition, this drug is also used to treat various types of cancer, including breast cancer, kidney cancer, advanced neuroendocrine tumors, or subependymal giant cell astrocytoma

Everolimus works by inhibiting the mammalian target of rapamycin (mTOR), an enzyme that plays an important role in controlling cell growth and development. Therefore, this drug can work as an immunosuppressant to prevent rejection reactions after organ transplantation and inhibit the development of cancer cells.

Everolimus - Alodokter

As a drug to prevent post-transplant organ rejection reactions, everolimus can be combined with other immunosuppressant drugs, such as ciclosporin or tacrolimus.

Everolimus trademark: Afinitor, Certican

What is Everolimus

Class Prescription drugs
Categories Immunosuppressant drugs
Benefits Prevents body rejection reactions after organ transplantation and treats cancer
Used by Adults and children
Everolimus for pregnant and lactating women Category D: There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations.

It is not known whether everolimus can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Medicine form Tablets

Warning Before Consuming Everolimus

Everolimus should only be consumed according to a doctor's prescription. Here are some things you need to pay attention to before taking everolimus:

  • Do not use everolimus if you are allergic to this drug. Tell your doctor if you are allergic to sirolimus or temsirolimus.
  • Tell your doctor if you have diabetes, high cholesterol, or an infectious disease.
  • Tell your doctor if you have or are currently suffering from lactose intolerance, liver disease, kidney disease, or have had a heart transplant.
  • Avoid close contact with people with infectious diseases that are easily contagious, such as flu or measles, while undergoing treatment with everolimus, because this drug can lower the body's immune system.
  • Tell your doctor if you plan to get vaccinated while on treatment with everolimus. This medicine may affect the effectiveness of the vaccine.
  • As much as possible, limit or avoid direct sun exposure and always use sunscreen when outdoor activities, because everolimus can increase the risk of skin cancer.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Use effective contraception to prevent pregnancy during treatment with everolimus.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor that you are taking everolimus if you plan to undergo certain medical procedures, such as surgery or dental surgery.
  • See your doctor immediately if you experience an allergic reaction to the drug, serious side effects, or an overdose after taking everolimus.

Dosage and Instructions for Use of Everolimus

The doctor will determine the dose of everolimus based on the patient's condition, age, and body response to the drug. Here are the doses of everolimus based on its intended use:

Purpose: Preventing body rejection reactions after kidney or heart transplant

  • Adults: Initial dose 0.75 mg, 2 times a day. Treatment is given immediately after transplantation.

Purpose: Preventing body rejection reactions after liver transplant

  • Adults: Initial dose is 1 mg, 2 times a day for 12 months. Treatment is given 30 days after transplant.

Purpose: Treating kidney cancer, breast cancer, advanced neuroendocrine tumors, or renal angiomyolipoma associated with tuberous sclerosis complex (TSC)

  • Adult: 10 mg, once a day.

Aim: Treating subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC)

  • Adult: 4.5 mg/m2, 1 time a day.
  • Children 1 years old: 4.5 mg/m2, 1 time a day.

Purpose: Treating partial onset seizures associated with tuberous sclerosis complex (TSC)

  • Adult: 5 mg/m2, 1 time a day.
  • Children aged 2 years: 5 mg/m2, 1 time a day.

How to Take Everolimus Correctly

Consume everolimus according to the doctor's recommendations and read the instructions for use on the drug packaging before taking the drug. Do not change the dose without consulting your doctor first.

Take everolimus regularly at the same time every day. Everolimus can be taken before or after meals. Swallow the medicine whole with the help of a glass of water. Do not chew or crush it.

If you have difficulty swallowing the tablet, you can mix the everolimus dispersible tablet in a glass of water before taking it.

If you forget to take everolimus, take it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

Make sure to carry out the control according to the schedule given by the doctor. During treatment with everolimus, you may be asked to have your blood pressure checked, complete blood count, or blood clotting factor indicators, such as INR, on a regular basis.

Avoid eating or drinking grapefruit juice while taking everolimus, as this may increase the risk of side effects.

Store everolimus at room temperature and place in a closed container. Keep this medicine away from direct sunlight and keep this medicine out of reach of children.

Interaction of Everolimus with Other Drugs

There are several drug interaction effects that can occur when everolimus is used with certain drugs, namely:

  • Reduced vaccine effectiveness or increased risk of infection if used with BCG vaccine, influenza vaccine, or measles vaccine
  • Increased risk of angioedema when used with ACE inhibitors, such as ramipril
  • Increased risk of developing rhabdomyolysis syndrome in transplant patients when used with simvastatin, lovastatin, or fibrates
  • Elevated blood levels of everolimus when used with ketoconazole, erythromycin, ritonavir, nefazodone, imatinib, verapamil, diltiazem, or dronedarone
  • Decreased effectiveness of everolimus when used with rifampicin, dexamethasone, carbamazepine, phenobarbital, phenytoin, efavirenz, or nevirapine
  • Increased risk of side effects when used with pimoxide, erfenadine, astemizole, cisapride, quinidine, or ergot alkaloids drugs
  • Increased blood levels of midazolam or octreotide
  • Increased risk of developing renal impairment, hemolytic uremic syndrome, or thrombotic thrombocytopenic purpura (TTP) when used with ciclosporin or tacrolimus
  • Increased risk of serious infection if used with thymoglobulin

Side Effects and Dangers of Everolimus

Some of the common side effects after taking everolimus are:

  • Nausea or vomiting
  • stomach ache
  • Diarrhea or constipation
  • Headache or dizziness
  • Dry mouth or thrush

Do an examination to the doctor if the side effects above do not subside. Immediately see a doctor if an allergic reaction occurs to the drug which is characterized by the appearance of an itchy and swollen rash, swollen eyes and lips, or difficulty breathing.

In addition, you should also go to the doctor immediately if you experience more serious side effects, such as:

  • Lung disease, which can be characterized by symptoms such as coughing, shortness of breath or difficulty breathing, wheezing, or pain in the chest
  • Infectious disease, which can be characterized by symptoms such as fever, chills, or a rash on the skin
  • Swelling of the hands, ankles, or feet
  • Wounds are hard to heal
  • Decreased sexual desire in men
  • Easy bruising or unusual bleeding

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