Table of contents:
- Doxorubicin is a chemotherapy drug to treat various types of cancer, such as breast cancer, prostate cancer, stomach cancer, thyroid cancer, liver cancer, or lymphoma
- What is Doxorubicin
- Warning Before Using Doxorubicin
- Doxorubicin Dosage and Instructions
- How to Use Doxorubicin Correctly
- Doxorubicin Interaction with Other Drugs
- Side Effects and Dangers of Doxorubicin
2023 Author: Autumn Gilbert | [email protected]. Last modified: 2023-11-27 07:39
Doxorubicin is a chemotherapy drug to treat various types of cancer, such as breast cancer, prostate cancer, stomach cancer, thyroid cancer, liver cancer, or lymphoma
Doxorubicin is an anthracycline type chemotherapy drug. This drug works by slowing or stopping the growth of cancer cells by blocking the enzyme topoisomerase type 2, an enzyme that cancer cells use to grow and develop.
Doxorubicin trademarks: Caelyx, Doxotil, Doxorubicin HCl, Kemodoxin, Naprodox, Sandobicin, Sindroxocin
What is Doxorubicin
|Categories||Chemotherapy drug type anthracycline|
|Benefits||Treating various types of cancer|
|Used by||Adults and children|
|Doxorubicin for Pregnant and Breastfeeding Mothers||Category D: There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations.
Doxorubicin can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor.
Warning Before Using Doxorubicin
The following are some things you need to pay attention to before using doxorubicin:
- Tell your doctor about any allergies you have. Doxorubicin should not be given to patients who are allergic to this drug or to other anthracycline drugs, such as daunorubicin, epirubicin, or idarubicin.
- Tell your doctor if you have anemia from chemotherapy, severe liver disease, heart disease, or have recently had a heart attack.
- Tell your doctor if you have ever had kidney disease, gout, or have had radiotherapy.
- Tell your doctor if you are taking any medications, supplements or herbal products.
- Tell your doctor that you are taking doxorubicin before undergoing certain medical procedures or surgery.
- Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Use effective contraception during treatment with doxorubicin up to 6 months after the last dose.
- Consult your doctor about the risks, side effects, and benefits of therapy with doxorubicin for children.
- As much as possible, avoid close contact with people who are suffering from infectious diseases that are easily transmitted, because they can increase your risk of contracting it.
- Tell your doctor if you plan to vaccinate with a live vaccine, such as the oral polio vaccine, while on therapy with
- See your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking doxorubicin.
Doxorubicin Dosage and Instructions
Doxorubicin will be given directly by a doctor or medical officer under the supervision of a doctor. The dose will be determined according to the condition being treated, body surface area (LPT), age, and the patient's response to treatment.
This drug will be injected through a vein ((intravenous/IV). In general, the following dosages of doxorubicin are used to treat certain types of cancer:
Condition: Cancer, such as breast cancer, ovarian cancer, or prostate cancer
- Alternative dose 1: 60–75 mg/m² every 21 days.
- Alternative dose 2: 60 mg/m² every 14 days.
- Alternative dose 3: 40–60 mg/m² every 21–28 days.
- Alternative dose 4: 20 mg/m² once a week.
Condition: Cancer, such as neuroblastoma, lymphoma, or leukemia
- Alternative dose 1: 35–75 mg/m² every 21 days.
- Alternative dose 2: 20–30 mg/m² once a week.
- Alternative dose 3: 60–90 mg/m² administered over 96 hours, every 3-4 weeks.
How to Use Doxorubicin Correctly
Doxorubicin will be given by a doctor or medical officer under the supervision of a doctor. This drug will be given by injection or intravenously into a vein.
In addition, to treat cancer of the bladder wall, the drug can be inserted directly into the bladder (intravesical chemotherapy).
Doxorubicin is a drug that can cause tissue damage and blistering. Immediately notify the doctor or nurse if the infused area is swollen and red in color. You also need to tell your doctor or nurse if doxorubicin comes out of the IV and gets on the skin.
Drink lots of fluids while taking doxorubicin to prevent kidney problems and speed up the movement of the drug to all parts of the body.
If treatment with doxorubicin causes nausea, you should not eat before taking medication or eat small but frequent meals. If needed, you can contact your doctor to prescribe medication that can reduce nausea.
Before and during treatment with doxorubicin, the doctor will ask you to undergo regular blood tests to check the number of blood cells and other substances in the blood. The doctor will also check liver function and kidney function.
Doxorubicin Interaction with Other Drugs
Some drug interactions that can occur if doxorubicin is used with certain drugs include:
- Reduced blood levels of doxorubicin when used with phenobarbital, phenytoin, saquinavir, nelfinavir, indinavir, carbamazepine, or dexamethasone
- Increased blood levels of doxorubicin when used with paclitaxel
- Increased blood levels of doxorubicin and the effect of doxorubicin when used with itraconazole, ketoconazole, quinidine, or verapamil
- Increased risk of bladder inflammation when used with cyclophosphamide
- Increased risk of liver damage when used with mercaptopurine
- Increased risk of heart muscle damage when used with trastuzumab
- Increased risk of bone marrow damage, decreased blood cell count, seizures, and coma when used with ciclosporin
- Increased risk of serious infection when used with live vaccines, such as influenza vaccine
Side Effects and Dangers of Doxorubicin
The following are some of the side effects that can occur after taking doxorubicin:
- Nausea and vomiting
- Loss of appetite
- Hair loss during treatment
- Fungal infection on nails
- Thrush or sores in the mouth
- Urine, tears and sweat are reddish in color for several days after treatment
Consult a doctor if these side effects do not improve or get worse. See a doctor immediately if you have an allergic reaction to the drug or serious side effects, such as:
- Flushing in the face, neck or chest (flushing)
- Signs and symptoms of heart failure, such as swelling in the legs, unusual tiredness, or difficulty breathing
- Difficulty breathing or wheezing
- Easy bruising or bloody stools
- Fever, cough, or diarrhea that doesn't stop
- In women, no menstruation or menstrual cycle changes
- Chest pain or fast or irregular heart rate
- Sunburn or skin redness, blisters, and pain
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