Darunavir - Benefits, dosage and side effects

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Darunavir - Benefits, dosage and side effects
Darunavir - Benefits, dosage and side effects
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Darunavir is a drug to treat HIV infection. This drug will be combined with ritonavir or other HIV drugs for better treatment effectiveness

Darunavir is an antiviral protease inhibitor class. By inhibiting the work of this enzyme, it will reduce the number of viruses, so that the immune system can work better and the risk of complications due to HIV infection can also be reduced.

Darunavir - Alodokter

Please note, this drug cannot cure or prevent HIV/AIDS transmission.

darunavir trademark: Prezista

What is Darunavir

Class Prescription drugs
Categories Protease inhibitor antivirus
Benefits Controlling HIV infection
Consumed by Adults and children over 3 years old
Darunavir for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not known whether darunavir can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Medicine form Tablets

Warning Before Taking Darunavir

Before taking darunavir, you need to pay attention to the following things:

  • Do not use darunavir if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Darunavir should not be used in children under 3 years of age.
  • Tell your doctor if you have or have had hemophilia, diabetes, high cholesterol, sulfa allergies, heart disease, or liver disease, such as hepatitis C or B.
  • Tell your doctor that you are taking darunavir if you are going to have any surgery, including dental surgery.
  • Tell your doctor if you are taking any medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • See your doctor immediately if you have an allergic reaction to the drug, serious side effects, or an overdose after taking darunavir.

Dose and Rules for Use of Darunavir

Darunavir should only be used as directed by a doctor. The following are general doses of darunavir based on the patient's age, weight, and medical history:

Patients who have never had treatment

  • Adults: 800 mg once daily, in combination with ritonavir 100 mg.
  • Children aged 3–17 years weighing 15–<30 kg: 600 mg once daily, in combination with ritonavir 100 mg.
  • Children aged 3–17 years weighing 31–39 kg: 675 mg once daily, in combination with ritonavir 100 mg.
  • Children aged 3–17 years weighing over 40 kg: 800 mg once daily, in combination with ritonavir 100 mg.

Patients who have already undergone treatment

  • Adults: 600 mg, 2 times daily, in combination with ritonavir 100 mg.
  • Children 3–17 years weighing 16–29 kg: 375 mg 2 times daily, in combination with ritonavir 48 mg.
  • Children 3–17 years weighing 31–39 kg: 450 mg 2 times daily, in combination with ritonavir 60 mg.
  • Children 3–17 years weighing over 40 kg: 600 mg 2 times a day, in combination with ritonavir 100 mg.

How to Take Darunavir Correctly

Follow the doctor's advice and read the information on the medicine package before taking darunavir. Do not reduce or increase the dose without consulting your doctor first.

Darunavir can be taken with food. Try to take darunavir at the same time every day for maximum treatment.

Keep taking this medicine even if you feel well. Do not stop taking this medicine without consulting your doctor.

Swallow the tablet whole with the help of a glass of water. Do not chew or crush the tablet.

If you forget to take darunavir, it is recommended to take it immediately if the gap between the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

During treatment with darunavir, your doctor may ask you to undergo regular he alth checks, including blood tests, blood sugar and cholesterol tests, or liver function tests. Follow the examination schedule given by the doctor.

To avoid transmitting HIV infection, the use of darunavir should be accompanied by preventive measures, such as using condoms during sexual intercourse or not sharing needles.

Store darunavir in a dry place and avoid direct sunlight. Keep this medicine out of reach of children.

Interaction of Darunavir with Other Drugs

The following are some drug interactions that can occur when darunavir is used together with other drugs:

  • Increased blood levels of darunavir when used with ritonavir or cobicistat
  • Decreased therapeutic effect of darunavir when used with rifampicin, lopinavir, carbamazepine, phenobarbital, or phenytoin
  • Increased effectiveness of salmeterol, alfuzosin, amiodarone, bepridil, quinidine, pimozide, oral midazolam, simvastatin, triazolam, or lovastatin

Side Effects and Dangers of Darunavir

Some of the side effects that can occur after taking darunavir are:

  • stomach ache
  • Nausea or vomiting
  • Constipation or diarrhea
  • Rash
  • Headache
  • Accumulation of fat on the back and stomach

Consult your doctor if the side effects above do not subside immediately or are getting worse. You need to see a doctor immediately if you experience an allergic reaction to a drug or a more serious side effect, such as:

  • Losing weight
  • Unusual tired
  • Muscle or joint pain
  • Numbness or tingling in the hands or feet
  • Rash with peeling or blistering of the skin
  • Symptoms of infection, which can be characterized by fever, persistent cough, or sore throat that doesn't go away
  • Jaundice, dark urine, severe stomach pain, or loss of appetite

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