Ivabradine - Benefits, dosage and side effects

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Ivabradine - Benefits, dosage and side effects
Ivabradine - Benefits, dosage and side effects
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Ivabradine is a drug to treat heart failure. This drug is also used to relieve chest pain or chronic stable angina in patients with coronary heart disease

Ivabradine will help slow down the heart rate by affecting the electrical activity in the heart. That way, the heart's work in pumping blood will be lighter and the risk of aggravation of complaints in heart failure can be reduced.

Ivabradine - Alodokter

This drug can be used by adults with heart failure or children over the age of 6 months. This medicine should not be used carelessly and according to a doctor's prescription.

Ivabradine trademark: Coralan, Farcor 5, Farcor 7, 5

What is Ivabradine

Class Prescription drugs
Categories Heart medicine
Benefits Treating heart failure or relieving stable angina in patients with coronary heart disease.
Consumed by Adults and children aged 6 years
Ivabradine for pregnant and lactating women Category N: Not yet categorized. However, this drug should not be used by pregnant women. Use effective contraception while taking ivabradine. It is not known whether it is absorbed into breast milk or not. Breastfeeding mothers should not take this drug.
Medicine form Tablets

Warning Before Taking Ivabradine

Ivabradine is available in tablet form and its use must be based on a doctor's prescription. There are several things that need to be considered before taking this drug, including:

  • Do not take ivabradine if you are allergic to this drug. Always tell your doctor about any allergies you have.
  • Tell your doctor if you have or have had liver disease, hypotension, kidney disease, retinal disease, heart rhythm disturbances, including a slow, irregular heartbeat, or have sick sinus syndrome.
  • Tell your doctor if you are using a pacemaker or pacemaker.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Use effective contraception during treatment with ivabradine.
  • Take regular check-ups with your doctor during your treatment with ivabradine.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Do not drive or do activities that require alertness after taking ivabradine, as this drug can cause dizziness and visual disturbances, including blurred vision.
  • See your doctor immediately if you experience an allergic reaction to the drug, a more serious side effect, or an overdose after taking ivabradine.

Dosage and Instructions for Use of Ivabradine

The dose of ivabradine for each patient may vary, depending on the condition to be treated and the patient's response to treatment. In children, the dose of ivabradine will be determined by the doctor based on the patient's weight.

The following are general doses of ivabradine based on the condition you want to treat:

Condition: Heart failure

  • Adults: The initial dose is 5 mg, taken 2 times a day. After 2 weeks, the dose can be increased or decreased depending on the patient's heart rate. Maximum dose 7.5 mg, 2 times a day.
  • Elderly: The initial dose is 2.5 mg, taken 2 times a day, the dose can be increased or decreased depending on the patient's response to treatment.
  • Children aged 6 years with body weight >40 kg: The initial dose is 2.5 mg, taken 2 times a day, the dose can be increased or decreased, depending on the patient's response to treatment.

Condition: Stable angina pectoris

  • Adults: The initial dose does not exceed 5 mg, taken 2 times a day. The dose may be increased to 7.5 mg, 2 times daily, after 3–4 weeks, depending on the patient's response to the drug. Reduce dose to 2.5 mg, 2 times daily, if patient has bradycardia.
  • Elderly aged 75 years: 2.5 mg, taken 2 times a day, the dose can be increased or decreased depending on the patient's response to the drug.

How to Take Ivabradine Correctly

Follow the doctor's advice and read the instructions on the medicine package before taking ivabradine. Do not reduce or increase the dose without consulting your doctor.

Take ivabradine with meals. Avoid consuming grapefruit while taking ivabradine, as it can increase the risk of side effects. Tell your doctor if you have difficulty swallowing.

It is recommended to take ivabradine regularly at the same time every day, i.e. in the morning and evening, for maximum treatment effect.

If you forget to take ivabradine, wait until your next schedule. Do not double the dose to make up for the missed dose.

Continue to continue treatment as recommended by the doctor, even though the condition has improved. Do not stop taking the drug, except on the doctor's instructions.

Conduct regular he alth checks to the doctor while undergoing treatment with ivabradine. He alth checks, such as heart checks and ECG, need to be done regularly to monitor the progress of the condition and the effectiveness of the drug.

Store ivabradine tablets in a closed container in a cool temperature. Protect this medication from exposure to direct sunlight. Keep this medicine out of reach of children.

Interaction of Ivabradine with Other Drugs

Using ivabradine together with other drugs can cause drug-drug interactions, including:

  • Increased risk of fatal side effects when used with ketoconazole, fluconazole, itraconazole, azithromycin, clarithromycin, erythromycin, ritonavir, darunavir, verapamil, diltiazem, or nefazodone
  • Increased risk of QT prolongation due to decreased heart rate, when used with quinidine, pimozide, disopyramide, or ziprasidone
  • The effectiveness of ivabradine decreases when used with rifampicin, phenytoin, or barbiturate drugs

In addition, a decrease in the effectiveness of ivabradine may occur if this drug is taken with the herbal medicine St. John's wort.

Side Effects and Dangers of Ivabradine

Some of the side effects that may appear after taking ivabradine are dizziness, unusual tiredness, visual disturbances such as seeing a halo image. Check with your doctor if the side effects above don't go away or get worse.

Immediately see a doctor if an allergic reaction occurs to a drug or a more serious side effect, such as:

  • The heart rate is very slow, in children this symptom is usually accompanied by difficulty eating, shortness of breath, skin looks bluish
  • Chest pain that is getting worse, chest feels pressured
  • Dizzy so heavy that you faint
  • Extremely tired
  • Headache or blurred vision
  • Heart palpitations or fast heartbeat

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