Stavudine - Benefits, dosage and side effects

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Stavudine - Benefits, dosage and side effects
Stavudine - Benefits, dosage and side effects

Stavudine is a drug to treat HIV infection. For maximum treatment results, the use of stavudine can be combined with other HIV drugs. Please note, this drug cannot cure or prevent HIV/AIDS transmission

Stavudine belongs to the type of antiviral drug nucleoside reverse transciptase inhibitors (NRTI). This drug works by reducing the amount of the HIV virus in the body, so the immune system can work better. That way, the risk of HIV complications can be reduced.

Stavudine - Alodokter
Stavudine - Alodokter

stavudine trademark: Staviral

What is Stavudine

Class Prescription drugs
Categories Antivirus nucleoside reverse transciptase inhibitors (NRTI)
Benefits Controlling HIV infection
Consumed by Adults and children
Stavudine for pregnant and lactating mothers Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Stavudine can be absorbed into breast milk. Therefore, consult your doctor about the benefits and risks of taking stavudine while breastfeeding.

Medicine form Tablets

Warning Before Taking Stavudine

Before taking stavudine, you need to pay attention to the following things:

  • Do not use stavudine if you are allergic to this drug. Tell your doctor about any allergies you have.
  • Tell your doctor if you have or have had liver disease, kidney disease, diabetes, pancreatitis, gallstones, obesity, peripheral neuropathy, or a history of long-term use of HIV medications.
  • Tell your doctor if you have a drinking habit or suffer from alcoholism.
  • Tell your doctor that you are taking stavudine if you are going to have any surgery, including dental surgery.
  • Tell your doctor if you are taking any medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • See your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking stavudine.

Dosage and Rules for Use of Stavudine

Stavudine should only be consumed based on a doctor's prescription. The following are common doses of stavudine to treat HIV infection based on the patient's age and weight:

  • Adult weighing <60 kg: 30 mg every 12 hours
  • Adult 60 kg: 40 mg every 12 hours
  • Newborn–13 days: 0.5 mg/kg every 12 hours
  • Children aged 14 days <30 kg: 1 mg/kgBB every 12 hours
  • Children aged 14 days 30 kg: 30 mg every 12 hours
  • Children aged 14 days 60 kg: 40 mg every 12 hours

How to Take Stavudine Correctly

Follow the doctor's advice and read the information on the medicine package before taking stavudine. Do not reduce or increase the dose without consulting your doctor first.

Stavudine can be taken before or after meals. Try to take stavudine at the same time every day for maximum treatment. Do not stop taking this medicine without consulting your doctor.

If you forget to take stavudine, it is recommended to take it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

During treatment with stavudine, your doctor may ask you to have regular blood tests to monitor your body's response to the drug. Follow the examination schedule given by the doctor.

To avoid transmission of HIV infection, the consumption of stavudine must be accompanied by preventive measures, such as practicing safe sex behavior, using condoms during sexual intercourse, or not sharing needles.

Store stavudine in a dry place and avoid exposure to direct sunlight. Keep this medicine out of reach of children.

Interaction of Stavudine with Other Drugs

The following are some of the interactions between drugs that can occur if stavudine is used together with other drugs:

  • Decreased effectiveness of stavudine when used with zidovudine, ribavirin, or doxorubicin
  • Increased risk of peripheral neuropathy when used with interferon or isoniazid
  • Increased risk of developing pancreatitis, peripheral neuropathy, or liver damage when used with didanosine or hydroxycarbamide

Side Effects and Dangers of Stavudine

Some of the side effects that can occur after taking stavudine are:

  • Diarrhea
  • Rash
  • Nausea or vomiting
  • Headache
  • Difficulty sleeping
  • Accumulation of fat in the upper back or abdomen

Consult your doctor if the side effects above do not subside immediately or are getting worse. You need to see a doctor immediately if you experience an allergic reaction to a drug or a more serious side effect, such as:

  • Lactic acidosis, especially when combined with didanosine and consumed by pregnant women
  • Peripheral neuropathy which can be characterized by certain symptoms, such as numbness, tingling, or pain in the hands or feet
  • Pancreatitis or inflammation of the pancreas
  • Visibility
  • Fast or irregular heartbeat
  • Weight loss
  • Jaundice, dark urine, upper right abdominal pain, or loss of appetite
  • Infectious disease that can be characterized by symptoms such as fever, cough, or sore throat