Vinorelbine - Benefits, dosage and side effects

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Vinorelbine - Benefits, dosage and side effects
Vinorelbine - Benefits, dosage and side effects

Vinorelbine or vinorelbine tartrate is a drug to treat several types of cancer. This drug is used in chemotherapy procedures to treat cervical cancer, breast cancer, ovarian cancer, and non-small cell lung cancer (NSCLC)

Vinorelbine works by inhibiting the process of cell division, so that the growth of cancer cells in the body can be slowed or stopped. Vinorelbine is usually combined with other chemotherapy drugs.

Vinorelbine - Alodokter
Vinorelbine - Alodokter

Vinorelbine trademark: Navelbine, Vinsoh, Vinorelsin, Vinorkal, Vinorelbine Tartrate

What is Vinorelbine

Class Prescription drugs
Categories Chemotherapy or anticancer drugs
Benefits Treating several types of cancer, such as cervical cancer, breast cancer, ovarian cancer, and non-small cell lung cancer (NSCLC)
Used by Adult
Vinorelbine for pregnant and lactating women Category D: There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations.

Vinorelbine is not known whether it can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Medicine form Soft capsules and injection

Warning Before Using Vinorelbine

Vinorelbine must be used with a doctor's prescription. The following are some things to consider before using vinorelbine:

  • Tell your doctor about any allergies you have. Vinorelbine should not be used by patients who are allergic to this drug.
  • Tell your doctor if you have or are currently suffering from liver disease, neurological disorders, heart disease, intestinal obstruction, tingling, or diseases of the spinal cord that can cause anemia, leukopenia, or thrombocytopenia.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Use contraception to prevent pregnancy while on treatment with vinorelbine.
  • Tell your doctor if you have recently had radiation therapy or cancer treatment.
  • Tell your doctor if you want to immunize or vaccinate with a live vaccine, such as the typhoid vaccine, while taking vinorelbine. This is because these drugs can reduce the effectiveness of the vaccine.
  • Do not drink alcohol, drive a vehicle or engage in activities that require alertness while taking vinorelbine, as this drug can make you dizzy.
  • Use sunscreen and limit activities that expose you to direct sunlight during treatment with vinorelbine, as this medicine can make your skin more sensitive to sunlight and increase the risk of sunburn.
  • Tell your doctor if you are taking any other medicines, including supplements, or herbal products.
  • See your doctor immediately if you experience an allergic drug reaction, serious side effect or overdose after taking vinorelbine.

Pakia Vinorelbine Dosage and Rules

Vinorelbine will be given by the doctor, the dose will be determined based on the age, the patient's condition, and the body's response to the drug. In general, the following are the doses of vinorelbine for adults based on the dosage form of the drug, body surface area (LPT) and the patient's condition:

Forms of intravenous (IV) injection

  • Condition: Cervical cancerThe dose is 30 mg/m2, on days 1 and 8 of a 21 day cycle.

  • Condition: Breast cancer, ovarian cancerThe dose is 25 mg/m2, every 7 days.

  • Condition: Non-small cell lung cancer (NSCLC)The dose is 30 mg/m2, once a week given by infusion for 20 -30 minutes if dissolved in 5% glucose solution. As combination therapy with cisplatin, the dose is 25–30 mg/m2, once a week

Soft capsule form

  • Condition: Non-small cell lung cancer (NSCLC)The dose is 60 mg/m2, once a week for 3 weeks. The dose can be increased to 80 mg/m2, once a week.

How to Use Vinorelbine Correctly

Injectable Vinorelbine will be given in the hospital by a doctor or medical officer under the supervision of a doctor. Vinorelbine will be injected through a vein (IV/intravenous).

The doctor will inject vinorelbine according to the patient's condition. Follow the doctor's advice during treatment with vinorelbine.

For soft capsule vinorelbine preparations, follow the dosage given by the doctor. Do not increase or decrease the dose without consulting your doctor first.

Take this medicine regularly according to the schedule given by the doctor. Swallow the medicine with the help of water. Swallow the medicine whole, do not chew or crush it.

If you forget to take vinorelbine, take it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

Make sure to check with your doctor regularly while taking vinorelbine so that your doctor can monitor the progress of your condition.

Store vinorelbine in a tightly closed storage container, at room temperature, and away from sun exposure. Keep this medicine out of reach of children.

Interaction of Vinorelbine with Other Drugs

The following are some of the effects of drug interactions that may occur if vinorelbine is taken together with other drugs:

  • Increased risk of granulocytopenia when used with cisplatin
  • Increased risk of nerve cell damage when used with paclitaxel, itraconazole, or ketoconazole
  • Increased risk of pulmonary disorders when used with mitomycin
  • Increased risk of spinal cord damage when used with zidovudine
  • Increased risk of side effects when used with troleandomycin, verapamil, erythromycin, or ritonavir
  • Increased risk of infectious disease and decreased effectiveness of live vaccines, such as BCG vaccine, influenza vaccine, measles vaccine, or typhoid vaccine

Side Effects and Dangers of Vinorelbine

Some of the side effects that may occur after using vinorelbine are:

  • Nausea or vomiting
  • Tired or dizzy
  • Constipation or diarrhea
  • Muscle pain or joint pain
  • Injectable preparations may cause irritation, pain, redness, or bruising at the injection site
  • Hair loss

Do an examination to the doctor if the side effects above do not subside. Immediately see a doctor if an allergic reaction occurs to the drug which can be characterized by certain symptoms, such as an itchy and swollen rash, swollen eyes and lips, or difficulty breathing.

In addition, you should also go to the doctor immediately if you experience more serious side effects, such as:

  • Shortness of breath, coughing, or difficulty breathing
  • Mood changes
  • Severe constipation, stomach pain, or bloody stools
  • Numbness, tingling, and muscle weakness
  • Pain, redness, and peeling skin on hands or feet
  • liver disorders, characterized by nausea, vomiting, loss of appetite, stomach pain, jaundice, or dark urine
  • Leukopenia, which is characterized by fever, chills, mouth sores, easy bruising or bleeding, pale skin, cold hands and feet, or dizziness