Alendronate - Benefits, dosage and side effects

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Alendronate - Benefits, dosage and side effects
Alendronate - Benefits, dosage and side effects

Alendronate is a drug to prevent and treat osteoporosis, especially in postmenopausal women. This drug is also used in the treatment of Paget's disease, which is a disorder in the process of bone regeneration that causes bones to become brittle and crooked

Alendronate is a bisphosphonate drug. This drug slows bone loss by inhibiting bone resorption by osteoclasts. That way, bone strength will be maintained and the risk of fracture can be reduced.

Alendronate - Alodokter

In addition to treating postmenopausal osteoporosis, alendronate is also used to treat osteoporosis triggered by the use of corticosteroid drugs. The risk of osteoporosis due to corticosteroid use will increase with corticosteroid treatment for more than 3 months and with high doses.

Alendronate trademark: Alovell, Osteofar

What is Alendronate

Class Prescription drugs
Categories Bisphosphonates
Benefits Treatment of postmenopausal osteoporosis, osteoporosis induced by long-term use of oral corticosteroids, and Paget's disease.
Used by Adult
Alendronate for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

It is not yet known whether alendronate can be absorbed into breast milk or not. If you are breastfeeding, do not take this medicine without consulting your doctor first.

Medicine form Tablets

Warning Before Taking Alendronate

Alendronate should not be taken carelessly. Some things to consider before taking this drug are:

  • Tell your doctor about any allergies you have. Alendronate should not be taken by someone who is allergic to this drug or to other bisphosphonate drugs, such as ibandronate.
  • Tell your doctor if you have difficulty swallowing, difficulty sitting up straight, or low levels of calcium in your blood (hypocalcemia). Alendronate should not be given to patients who are suffering from this condition.
  • Tell your doctor if you have or are currently suffering from peptic ulcers, kidney disease, anemia, heart failure, heart disease, dental, gum and mouth disease, blood clotting disorders, hypertension, or cancer.
  • Tell your doctor if you smoke or are undergoing chemotherapy or radiotherapy.
  • Tell your doctor that you are taking alendronate if you plan to undergo dental treatment or surgery.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Do regular dental and oral examinations and go to the doctor immediately if you experience jaw pain during treatment with alendronate, because this drug can cause jawbone damage.
  • See your doctor immediately if you experience an allergic reaction, overdose, or more serious side effects after taking alendronate.

Dosage and Instructions for Use of Alendronate

Treatment with alendronate will generally be carried out in the long term, which is between 3-5 years, depending on the patient's condition. Alendronate is available in the form of tablets of 5 mg, 10 mg, 35, mg, 40 mg, and 70 mg.

The following are the doses of alendronate based on the condition you want to treat:

  • Condition: Postmenopausal Osteoporosis

For treatment, the dosage is 10 mg, once a day, or 70 mg, once a week. For prevention, the dosage is 5 mg, once a day, or 35 mg, once a week.

  • Condition: Osteoporosis triggered by the use of corticosteroid drugs

Dose of 5 mg, 1 time a day. Especially for postmenopausal women who do not receive hormone replacement therapy, the dose is 10 mg, once a day.

  • Condition: Paget's Disease

Dose 40 mg, 1 time a day, for 6 months. Treatment can be repeated if needed.

How to Take Alendronate Correctly

Follow the doctor's advice and read the information listed on the drug packaging label before taking alendronate. Do not reduce or increase the dose without consulting your doctor first.

Alendronate tablets are recommended to be consumed some time after waking up in the morning or 1 hour before breakfast. Swallow the tablet whole with the help of a glass of water. Do not mix alendronate with drinks other than water.

This medicine should not be taken with soft drinks, coffee, tea, milk, or fruit juices. Do not suck, crush or chew the medicine.

Do not lie down after taking this medicine. You are required to stand or sit up straight for 1 hour after taking alendronate. If you are taking other medications, supplements, vitamins, or antacids, wait at least 1 hour after taking alendronate.

It is recommended to take alendronate at the same time every day for maximum benefits.

During treatment with alendronate, the doctor will advise you to maintain a he althy diet and lifestyle to meet the needs of vitamin D and calcium.

If you forget to take alendronate, wait for the scheduled consumption the next day. Do not double the dose to make up for the missed dose.

Store alendronate tablets in a closed container in a cool room. Protect this medicine from direct sunlight, and keep the medicine out of reach of children.

Alendronate Interaction with Other Drugs

The following are the effects of drug interactions that can occur when alendronate is used with other drugs:

  • Increased risk of injury or irritation of the digestive tract when used with deferasirox, aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Decreased calcium levels in the blood (hypokalemia) when used with etelcalcetide
  • Decreased absorption of alendronate in the body when used with antacids or calcium supplements

Side Effects and Dangers of Alendronate

Some of the possible side effects after taking alendronate are:

  • Constipation or constipation
  • Diarrhea
  • Bloating or stomach ache
  • Nausea
  • bone pain, muscle pain, or joint pain

Do an examination to the doctor if the side effects above don't go away or get worse. Immediately see a doctor if there is an allergic reaction to the drug or a more serious side effect, such as:

  • Osteonecrosis of the jawbone, which can be characterized by symptoms such as tooth loss and pain or swelling in the jaw
  • Low levels of calcium (hypokalemia), which can be characterized by symptoms such as muscle stiffness, and tingling or a feeling like pins and needles around the mouth, fingers, or toes
  • Irritation and sores in the esophagus, which can be characterized by a burning sensation in the chest (heartburn), difficulty swallowing, pain when swallowing, or vomiting blood
  • Extremely severe muscle, bone, joint or leg pain

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