Avifavir - Benefits, dosage and side effects

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Avifavir - Benefits, dosage and side effects
Avifavir - Benefits, dosage and side effects

Avifavir is an antiviral drug that contains favipiravir. This drug has obtained an emergency use permit from the Indonesian Food and Drug Supervisory Agency (BPOM) to be used in the treatment of COVID-19, namely in patients aged 18 years and over with mild to moderate symptoms

Avifavir was developed in Russia, by the Russian Direct Investment Fund and ChemRar Group. Avifavir contains favipiravir. Favipiravir works by inhibiting the work of the RNA polymerase enzyme that is needed by viruses to reproduce.

Avifavir - Alodokter

Favipiravir is usually used to treat infections caused by the influenza virus. Because the use of favipiravir for Corona virus infection is still new, its effectiveness and safety in the treatment of COVID-19 is still being monitored.

What is Avifavir

Class Antivirus
Active Ingredients Favipiravir 200 mg
Categories Prescription drugs
Benefits Coping with influenza virus infection and COVID-19
Consumed by Adult age 18 years
Avifavir for pregnant and lactating women Category X: Studies in experimental animals and humans have shown any abnormalities to the fetus or a risk to the fetus. Drugs in this category should not be used in women who are or have the possibility of to get pregnant.

Avifavir is not known to be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine without consulting your doctor first.

Medicine form film-coated tablets

Warning Before Taking Avifavir

Avifavir can only be used according to a doctor's prescription. There are several things that must be considered before using this drug, including:

  • Tell your doctor about any allergies you have. Avifavir should not be given to patients who are allergic to this drug or to favipiravir.
  • Tell your doctor if you are pregnant, breastfeeding or planning a pregnancy. Avifavir should not be used in women who are pregnant or planning a pregnancy.
  • Tell your doctor if you have or are currently suffering from gout, immune system disorders, mental disorders, liver inflammation, fungal infections, asthma, tumors, or bacterial infections, including tuberculosis.
  • Tell your doctor if you have or have recently had shock, respiratory failure, arrhythmia, or heart attack.
  • Tell your doctor if you are on dialysis or have received an organ transplant.
  • Tell your doctor if you are addicted to alcohol or have ever experienced drug abuse.
  • Tell your doctor if you are taking any other medicines, including herbal medicines and supplements.
  • See your doctor immediately if you experience an allergic reaction to the drug or an overdose after taking Avifavir.

Avifavir Dosage and Instructions

The exact dose of Avifavir is not yet known to treat COVID-19. In phase II and III studies, the dose of Avifavir used in the treatment of COVID-19 was 1600 mg, twice daily on the first day, followed by 600 mg, twice daily on day two to day fourteen.

The use of Avifavir to treat Corona virus infection will be considered by the doctor according to the severity of the disease and the patient's condition.

How to Take Avifavir Correctly

Avifavir should only be consumed according to the doctor's prescription and advice. Do not increase or decrease the dose, and do not use the drug more than the recommended time.

Avifavir can be taken with or without food. However, to prevent gastric pain, it is recommended to take this drug with food or after meals.

Make sure there is enough space between one dose and the next. It is recommended to take avifavir at the same time every day.

Store Avifavir in a closed place in a cool temperature. Do not store it in a humid place or in direct sunlight. Keep this medicine out of reach of children.

Avifavir Interaction with Other Drugs

According to ongoing research, when used together with certain drugs, the favipiravir content in Avifavir can cause drug interactions in the form of:

  • Decreased effectiveness of amiodarone, atorvastatin, lovastatin, carbamazepine, chloroquine, cisapride, diclofenac, diltiazem, enzalutamide, erlotinib, ethinylestradiol, or ifosfamide
  • Decreased effectiveness of ketamine, ketorolac, ibuprofen, piroxicam, lansoprazole, omeprazole, methadone, nicardipine, naproxen, repaglinide, sorafenib, theophylline, tretinoin, verapamil, or warfarin
  • Increased risk of side effects of acyclovir, benzylpenicillin, cefalor, bisoprolol, captopril, cefdinir, cefazolin, citrulline, dexamethasone, digoxin, estradiol, everolimus, famotidine, allopurinol, or fexofenadine
  • Increased risk of side effects of grazoprevir, hydrocortisone, indacaterol, lenvatinib, morphine, nintedanib, oseltamivir, quinidine, paliperidone, ranitidine, simvastatin, tetracycline, vincristine, or zidovudine

Avifavir Side Effects and Dangers

The content of favipiravir in Avifavir can cause some complaints if used in excess.Some complaints that can appear are vomiting, weight loss, and movement disorders. However, further research is still needed to prove these side effects.

Immediately consult a doctor if you experience these complaints or other side effects after taking Afivafir, as well as if you experience an allergic reaction to the drug, which can be indicated by the appearance of an itchy rash on the skin, swelling of the lips and eyelids, or difficulty breathing. breathe.

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