Anakinra - Benefits, dosage and side effects

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Anakinra - Benefits, dosage and side effects
Anakinra - Benefits, dosage and side effects
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anakinra is a drug to relieve the symptoms of rheumatoid arthritis. It is also used in the treatment of neonatal onset multisystem inflammatory disease (NOMID) or interleukin-1 receptor antagonist deficiency

anakinra belongs to the class of interleukin-1 receptor antagonists. This drug works by inhibiting the activity of interleukin-1 alpha and beta (IL-1). IL-1 is responsible for triggering immune system responses and inflammation in the body. By inhibiting the work of IL-1, the inflammation and complaints that occur will also subside.

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What is Anakinra

Class Prescription drugs
Categories Interleukin-1 receptor antagonist
Benefits Relieves the symptoms of rheumatoid arthritis and treats NOMID (neonatal-onset multisystem inflammatory disease)
Used by Adults and children

anakinra for pregnant and lactating women

Category B: Animal studies have not shown any risk to the fetus, but there have been no controlled studies in pregnant women.

It is not yet known whether anakinra can be absorbed into breast milk or not. If you are breastfeeding, do not use this medicine before consulting your doctor.

Medicine form Inject

Warning Before Using Anakinra

anakinra is a drug that can only be used according to a doctor's prescription. Here are some things to note using anakinra:

  • Tell your doctor about any allergies you have especially. Anakinra should not be used by someone who is allergic to this drug.
  • Tell your doctor if you have frequent infections, fever, kidney disease, asthma, tuberculosis, or a weakened immune system, including HIV/AIDS.
  • Tell your doctor if you are taking certain medications, supplements or herbal products.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor that you are taking anakinra if you plan to undergo any surgical procedures, including dental surgery.
  • Avoid direct contact with someone who has an infectious disease that is easily transmitted, such as the flu or measles, as these drugs can increase your risk of infection.
  • Consult your doctor if you plan to vaccinate during treatment with ankinra.
  • See your doctor immediately if you experience an allergic reaction to the drug, serious side effects, or an overdose after using this drug.

Dosage and Instructions for Use Anakinra

The dose of anakinra given by the doctor may be different for each patient, depending on the condition to be treated and the patient's response to the drug.

anakinra will be injected under the skin (subcutaneously/SC). In general, the dosage of anakinra based on the condition to be treated is as follows:

Condition: Rheumatoid arthritis

  • Adults: 100 mg once a day.

anakinra can be used alone or in combination with disease modifying antirheumatic drugs or DMARDs that are not inhibitors of tumor necrosis factor alpha.

Conditions: Neonatal onset multisystem inflammatory disease (NOMID) otherwise known as infantile neurologic cutaneous articular syndrome (CINCA)

  • Adults and children: Initial dose 1–2 mg/kgBW, 1 time a day. The dose may be increased by 0.5–1 mg/kg to control active inflammation. The maximum dose is 8 mg/kgBB.

Condition: Deficiency of interleukin-1 receptor antagonist (DIRA)

  • Adults: Initial dose is 1–2 mg/kgBW, 1 time a day. The dose may be increased by 0.5–1 mg/kg to control active inflammation. The maximum dose is 8 mg/kgBB.

How to Use Anakinra Correctly

anakinra will be injected by a doctor or by medical personnel under the supervision of a doctor. During treatment with anakinra, follow the doctor's advice so that treatment is more effective.

When using anakinra, you need to undergo regular he alth checks to make sure there are no side effects. The doctor may also ask you to have regular blood tests to monitor the effectiveness of therapy.

Interaction of Anakinra with Other Drugs

Interaction effects that can occur when anakinra is used with certain drugs include:

  • Increased risk of serious infection with adalimumab, bariticinib, etanercept, fingolimod, or infliximab
  • Reduced effectiveness of live vaccines, such as the BCG vaccine or measles vaccine

Side Effects and Dangers of Anakinra

Side effects that can occur after using anakinra are:

  • Headache
  • Diarrhea
  • Joint pain
  • Nausea or vomiting
  • Soreness, redness, and irritation at the injected skin area

Tell your doctor if these side effects do not improve or get worse. Tell your doctor right away if you have an allergic reaction to the drug, which can be characterized by symptoms, such as an itchy rash, difficulty breathing, or swelling of the eyelids or face.

In addition, the use of anakinra can increase the risk of serious and potentially fatal infections. Tell your doctor immediately if you experience any symptoms of infection, such as:

  • Fever, chills, or bone pain
  • Cough with phlegm
  • Sore throat that doesn't get better

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