Table of contents:
- What is Topiramate
- Warning Before Consuming Topiramate
- Dosage and Rules for Use of Topiramate
- How to Take Topiramate Correctly
- Interaction of Topiramate with Other Drugs
- Side Effects and Dangers of Topiramate
Topiramate is a drug to relieve seizures due to epilepsy. Lennox-gastaut syndrome is one type of epilepsy that can be treated with this drug. Topiramate can also be used to prevent migraines. This medicine should only be used according to a doctor's prescription
How it works is not known with certainty. However, topiramate is thought to work by inhibiting the activity of signaling chemicals in the brain (neurotransmitters), so that abnormal electrical activity can be stopped. This way of working will help relieve seizures due to epilepsy.
Topiramate trademarks: Epilep, Topamax
What is Topiramate
|Benefits||Relieves seizures due to epilepsy and prevents migraine|
|Consumed by||Adults and children|
|Topiramate for pregnant and lactating women||Category D: There is positive evidence of risks to the human fetus, but the benefits may outweigh the risks, for example in dealing with life-threatening situations.
Topiramate can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.
|Medicine form||Capsules and tablets|
Warning Before Consuming Topiramate
Topiramate should only be used according to a doctor's prescription. Here are some things you need to pay attention to before taking topiramate:
- Do not take topiramate if you are allergic to this drug. Always tell your doctor about any allergies you have.
- Tell your doctor if you have or have ever had porphyria, glaucoma, kidney disease, breathing problems, depression, liver disease, osteoporosis, or acidosis
- Tell your doctor if you are taking certain medications, supplements or herbal products.
- See a doctor immediately if you experience very disturbing mood swings or if you are suicidal.
- Always drink adequate amounts of water during treatment with topiramate, to prevent dehydration, electrolyte disturbances, or kidney stones.
- Do not drive a vehicle or do activities that require alertness while taking topiramate, as this drug can cause dizziness.
- Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
- See your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking topiramate.
Dosage and Rules for Use of Topiramate
The dose of topiramate given by the doctor depends on the he alth condition and age of the patient. Here is the explanation:
Goal: Overcoming epilepsy
- Adults: The initial dose of 25 mg is taken at night for 1 week. The dose may be increased by 25–50 mg at intervals of 1–2 weeks. The maintenance dose is 100 mg per day. The maximum dose is 500 mg per day.
- Children aged 6 years: The initial dose is 0.5–1 mg/kgBW taken at night for 1 week. The dose can be increased by 0.5–1 mg/kgBW at 1–2 weeks apart.
Purpose: Prevent migraine
- Adults: The initial dose of 25 mg is taken at night for 1 week. The dose may be increased by 25 mg at 1 week intervals. The maintenance dose is 50–100 mg per day. The maximum dose is 200 mg per day.
Aim: Overcoming seizures in patients with Lennox-gastaut syndrome
- Adults: The initial dose is 25–50 mg taken at night for 1 week. The dose may be increased by 25–50 mg at intervals of 1–2 weeks. Maintenance dose 200–400 mg per day.
- Children aged 2 years: The initial dose of 25 mg is taken at night for 1 week. The dose can be increased by 1–3 mg/kg at 1–2 weeks apart. Maintenance dose 5–9 mg/kgBW per day.
How to Take Topiramate Correctly
Read the instructions on the medicine package first and follow the doctor's advice when taking topiramate. Do not reduce or increase the dose without consulting your doctor first.
Topiramate can be taken with or without food. Use a glass of water to swallow the tablet or capsule. Do not crush, chew or split the medicine as this may increase the risk of side effects.
Drink lots of water while undergoing treatment with this drug, to prevent kidney stones.
If you forget to take topiramate, take it as soon as you remember. If it is near the time of your next dose, ignore the missed dose and do not double the topiramate dose to make up for the missed dose.
Do regular check-ups during treatment with topiramate. Do not stop treatment without consulting your doctor first.
Store the topiramate in a place away from direct sunlight. Keep out of reach of children.
Interaction of Topiramate with Other Drugs
There are several possible interaction effects if topiramate is taken with certain drugs, including:
- Reduced blood levels of topiramate when used with carbamazepine or phenytoin
- Increased risk of hyperammonemia when used with valproic acid
- Increased levels of topiramate in the blood when used with hydrochlorothiazide
- Decreased levels of digoxin, pioglitazone, glibenclamide, in the blood
- Decreased effectiveness of birth control pills containing estrogen
- Increased lithium levels in the blood
Side Effects and Dangers of Topiramate
Side effects that may occur after taking topiramate include:
- Headache, nervousness, or drowsiness
- Numbness or tingling in the hands or feet
- Menstrual cycle disorders, one of which is not menstruating
- Easy bruising or nosebleeds
- Dry mouth
Check with a doctor if the complaints mentioned above don't go away or get worse. See your doctor immediately if you have an allergic reaction to the drug or experience more serious side effects, such as:
- Visibility problems, such as blurred vision, double vision, eye pain, or red eyes
- Seizures that occur more frequently or last longer
- Memory impairment or difficulty speaking
- Loss of coordination ability
- Chest pain, irregular heartbeat, fast breathing, or difficulty breathing
- Loss of appetite, stomach pain, or back pain
- Pain when urinating, difficulty urinating, or bloody, cloudy, or foul-smelling urine