Quetiapine - Benefits, dosage and side effects

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Quetiapine - Benefits, dosage and side effects
Quetiapine - Benefits, dosage and side effects
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Quetiapine is an antipsychotic drug that is useful for treating mental disorders, such as schizophrenia, bipolar disorder, or depression. This drug is available in 2 forms, namely immediate-release and extended-release tablets. Quetiapine should only be used with a doctor's prescription

Quetiapine immediate-release tablets will release the active substance into the bloodstream immediately, while the extended-release tablet releases the active substance into the bloodstream gradually. Quetiapine extended-release tablets can be used in combination with other antidepressant drugs, to treat major depression.

Quetiapine - Alodokter

Quetiapine trademarks: Quetvell, Seroquel, Seroquel XR and Soroquin XR

What is Quetiapine

Class Antipsychotic drugs
Categories Prescription drugs
Benefits Treating schizophrenia, bipolar disorder, and depression
Used by Adults and children over 10 years
Quetiapine for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women. Drugs should only be used if the expected benefit outweighs the risk. to the fetus.

Quetiapine can be absorbed into breast milk. If you are breastfeeding, do not use this medicine without consulting your doctor first.

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Warning Before Using Quetiapine

Quetiapine should not be used carelessly. Follow the doctor's recommendations while undergoing treatment with this medicine. Before taking quetiapine, you need to pay attention to the following things:

  • Tell your doctor if you have a history of allergies to quetiapine or any other drug allergies.
  • Tell your doctor if you are taking any other medicines, including supplements and herbal products.
  • Tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.
  • Tell your doctor if you have dementia. Quetiapine should not be used in psychosis due to dementia.
  • Tell your doctor if you are taking quetiapine before any surgery, including dental surgery.
  • Do not drive, use machinery, or engage in activities that require alertness, while taking quetiapine, as this medicine may make you dizzy or drowsy.
  • Do not consume alcoholic beverages while taking quetiapine, as this can increase the risk of fatal side effects.
  • Do not use quetiapine for children younger than 10 years.
  • Avoid excessive exercise or outdoor activities while taking quentiapine, as this drug can put you at higher risk for heatstroke.
  • Tell your doctor if you have or are currently suffering from liver disease, heart disease, hypertension, hypotension, low white blood cell count, diabetes, difficulty swallowing, hypercholesterolemia, enlarged prostate (BPH), glaucoma, constipation, and seizures.
  • See your doctor immediately if you experience an allergic reaction to the drug or an overdose after taking quetiapine.

Dosage and Instructions for Use of Quetiapine

Quetiapine should only be used according to a doctor's prescription. The dose of quetiapine varies, depending on the type of preparation, the condition to be treated, and the age of the patient.

For extended-release preparations, it will be given once a day with the same dose as immediate-release preparations. The following is the distribution of quetiapine doses based on the patient's condition:

Condition: Schizophrenia

Immediate-release tablets for adults:

  • Day 1: 25 mg, 2 times a day
  • Days 2 and 3: the dose is increased to 25–50 mg, divided 2–3 times a day
  • Day 4: 150 mg 2 times a day. After the 4th day the dose can be adjusted according to the patient's response.
  • Maximum dose: 750 mg per day

Immediate-release tablets for >12 year olds:

  • Day 1: 50 mg, 2 times a day
  • Day 2: 100 mg, 2 times a day
  • Day 3: 200 mg, 2 times a day
  • Day 4: 300 mg, 2 times a day
  • Day 5: 400 mg, 2 times a day
  • Maintenance dose: 400–800 mg per day, divided into 2 or 3 doses
  • Maximum dose: 800 mg per day

Condition: Bipolar disorder mania episode

Immediate-release tablets for adults:

  • Day 1: 100 mg, 2 times a day
  • Day 2: 200 mg, 2 times a day
  • Day 3: 300 mg, 2 times a day
  • Day 4: 400 mg, 2 times a day
  • Maintenance dose: 400-800 mg per day in separate doses
  • Maximum dose: 800 mg per day

Immediate-release tablets for >10 years old:

  • Day 1: 50 mg, 2 times a day
  • Day 2: 100 mg, 2 times a day
  • Day 3: 200 mg, 2 times a day
  • Day 4: 300 mg, 2 times a day
  • Day 5: 400 mg, 2 times a day
  • Maintenance dose: 400-600 mg per day, divided into 2 or 3 doses
  • Maximum dose: 600 mg per day

Condition: Depressive episode of bipolar disorder

Immediate-release and extended-release tablets for adults:

  • Day 1: 50 mg, once daily
  • 2nd day: 100 mg, once daily
  • Day 3: 200 mg, once daily
  • Day 4: 300 mg, once daily
  • Maintenance dose: 300 mg, once daily
  • Maximum dose: 300 mg per day

Condition: Depression

Extended-release tablets for adults:

  • Day 1: 50 mg, once daily
  • Day 2: 50 mg, once daily
  • Day 3: 150 mg, once daily
  • Maintenance dose: 150-300 mg, once daily
  • Maximum dose: 300 mg per day

How to Use Quetiapine Correctly

Follow the doctor's advice and instructions while taking quetiapine. If you are taking quetiapine immediate-release tablets, you can take them before or after meals.

If you are taking quetiapine extended-release tablets, you can take it on an empty stomach without food.

Do not cut, chew or crush the tablet. Swallow whole with a glass of water. Quetiapine should be taken regularly at the same time every day to maximize drug performance.

If you forget to take quetiapine, take it as soon as you remember. If it is near the time of your next dose, skip the missed dose and continue your regular dosing schedule. Do not double your dose of quetiapine to make up for a missed dose without your doctor knowing.

Keep taking this medicine even if you feel well. Do not stop taking the drug without consulting your doctor first.

Take control according to the schedule given by the doctor while you are undergoing treatment with quetiapine, so that the condition of the disease and response to therapy can be monitored.

Interaction of Quetiapine with Other Drugs

Some of the interaction effects that can occur if quetiapine is used with other drugs are:

  • Heart rhythm disturbances if taken with antiarrhythmic drugs, antipsychotics, antibiotics, pentamidine, and methadone
  • Increased drowsiness when taken with benzodiazepines, muscle relaxants, pain relievers, antihistamines, sedatives, and barbiturates
  • Reduction of blood pressure if taken with antihypertensive drugs
  • Increased risk of side effects of quetiapine if taken with antifungal drugs, drugs to treat HIV, and antidepressants
  • Decreased performance of quetiapine when taken with anticonvulsants, rifampin, and St. John's wort
  • Lowering the effectiveness of drugs to treat Parkinson's disease, such as levodopa, pramipexole, or ropinirole

Side Effects and Dangers of Quetiapine

Some of the common side effects after using quetiapine are:

  • Dry mouth
  • Constipation
  • stomach ache
  • Dizzy
  • Nausea
  • Vomiting
  • Gain weight

Check with a doctor if the complaints mentioned above don't go away or get worse. Call your doctor immediately if you have an allergic reaction to the drug or experience more serious side effects, such as:

  • Fever
  • Fainted
  • Seizure
  • Excessive sweat
  • Stiff muscles
  • Blurred vision
  • Movement becomes uncontrollable
  • Difficult urination
  • irregular heartbeat (arrhythmia)

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