Clarithromycin - Benefits, dosage and side effects

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Clarithromycin - Benefits, dosage and side effects
Clarithromycin - Benefits, dosage and side effects

Clarithromycin is an antibiotic drug to treat bacterial infections of the respiratory tract, digestive tract, and skin. Several types of bacteria that cause infections that can be treated with this drug are H. influenzae, S. pneumoniae, M. pneumoniae, S. aureus, and M. avium

Clarithromycin works by interfering with the production of proteins that are essential for bacterial growth. That way the bacteria will stop growing and eventually die. This drug can only be used to treat bacterial infections and cannot be used to treat viral infections.

Clarithromycin - Alodokter

Clarithromycin trademarks: Abbotic, Bicrolid 250, Bicrolid 500, Comtro, Clapharma, Clarithromycin, Clarolid 500, Hecobac 500, Orixal

What is Clarithromycin

Class Prescription drugs
Categories Antibiotic macrolide
Benefits Treating bacterial infections in the respiratory tract, digestive tract, and skin.
Consumed by Adults and children aged 1 years
Clarithromycin for pregnant and lactating women Category C: Animal studies have shown adverse effects on the fetus, but there are no controlled studies in pregnant women.

Drugs should only be used if the expected benefit outweighs the risk to the fetus.

Clarithromycin can be absorbed into breast milk. If you are breastfeeding, do not take this medication without telling your doctor.

Shapes Tablets, caplets and syrup

Warning Before Taking Clarithromycin

Clarithromycin can only be used according to a doctor's prescription. Before taking clarithromycin, you need to pay attention to the following things:

  • Do not use the drug if you are allergic to clarithromycin and other macrolide antibiotics, such as azithromycin and erythromycin.
  • Tell your doctor if you are taking any other medicines, including supplements and herbal products.
  • Tell your doctor if you have or have ever had dehydration, hypomagnesemia, hypokalemic liver disease, kidney disease, myasthenia gravis, or heart disease, such as a heart rhythm disorder or coronary heart disease.
  • Tell your doctor that you are taking clarithromycin, if you are going to have any surgery, including dental surgery.
  • Tell your doctor if you are pregnant, breastfeeding, or planning a pregnancy.
  • Tell your doctor if you plan to vaccinate with a live vaccine, such as the typhoid vaccine, as clarithromycin can reduce the effectiveness of the vaccine.
  • Do not take clarithromycin if you are on treatment with aminoglycosides, astemizole, cisapride, diuretics, digoxin, ergotamine, pimozide, terfenadine, or anticoagulant drugs.
  • See your doctor immediately if you have an allergic reaction, serious side effects, or overdose after taking clarithromycin.

Dosage and Instructions for Use of Clarithromycin

The following are the general doses of clarithromycin which are divided according to the patient's condition:

Condition: Helicobacter pylori infection that causes stomach ulcers

  • Adults: If used as a 3-drug combination therapy, the dose is 500 mg 2 times a day, for 7–14 days. Meanwhile, if used in combination therapy with 2 drugs, the dose is 500 mg 2-3 times a day, for 14 days.

Condition: Respiratory, skin, or soft tissue infections, caused by bacteria

  • Adults: 250–500 mg 2 times a day, for 7–14 days.
  • Children: 7.5 mg/kgBW 2 times a day, for 5–10 days.

How to Take Clarithromycin Correctly

Follow the doctor's advice and read the instructions on the medicine package before using clarithromycin. Clarithromycin can be taken before or after meals.

Swallow the medicine in tablet or caplet form with a glass of water. Do not chew or split the medicine, swallow the medicine whole. For medicine in syrup form, use a measuring spoon so that the dose of medicine consumed is appropriate.

Make sure there is enough time between one dose and the next. Try to take clarithromycin at the same time every day to maximize the effectiveness of the drug.

If you forget to take clarithromycin, it is recommended to do it immediately if the break with the next consumption schedule is not too close. If it's close, ignore it and don't double the dose.

Clarithromycin is usually taken for 1-2 weeks, depending on the type and severity of the infection. Take the medicine according to the time prescribed by the doctor to reduce the risk of recurrence of the condition.

Store clarithromycin in a cool, dry and protected from direct sunlight. Keep medicine out of reach of children.

Clarithromycin Interactions with Other Drugs

There are several drug interactions that can occur if clarithromycin is used in combination with other medicines. The effects of drug interactions that can occur include:

  • Causes ergot poisoning, resulting in constriction of blood vessels when used with ergotamine
  • Increased risk of QT prolongation when used with astemizole, cisapride, pimozide, or terfenadine
  • Increase blood levels of colchicine
  • Increases risk of developing hypoglycemia when used with diabetes medications, such as insulin or pioglitazone
  • Increases risk of bleeding if used with anticoagulants, such as warfarin
  • Increases risk of ear damage when used with aminoglycosides
  • Lower blood levels of clarithromycin when used with efavirenz or rifampicin
  • Increases the drowsiness effect of midazolam
  • Increases the risk of digoxin poisoning
  • Lower the effectiveness of carbamazepine or phenytoin

Side Effects and Dangers of Clarithromycin

Side effects that may occur after taking clarithromycin are:

  • Diarrhea
  • Nausea and vomiting
  • Indigestion
  • Stomach feels bloated or sick to the stomach
  • Headache
  • Irritation of the sense of taste or smell
  • Mouth sores

Check with a doctor if the side effects above don't go away or get worse.

You are advised to go to the doctor immediately if you experience an allergic drug reaction or more serious side effects, such as:

  • Hearing ability
  • Visibility
  • Mood changes
  • muscles feel weak
  • The color of urine is darker
  • irregular heartbeat
  • severe diarrhea
  • chest pain
  • Skin and eyes are yellowish (jaundice)

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